Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOPe 2.05
  2. 1815291Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 1826588Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 1826589Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 1826923Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 1826950Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
  7. 1826966Species Human (Homo sapiens) [TaxId:9606] [117424] (29 PDB entries)
    Uniprot P28845

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 1xu7:
    1. 1826975Domain d1xu7a_: 1xu7 A: [116048]
      complexed with cps, ndp
    2. 1826976Domain d1xu7b_: 1xu7 B: [116049]
      complexed with cps, ndp
    3. 1826977Domain d1xu7c_: 1xu7 C: [116050]
      complexed with cps, ndp
    4. 1826978Domain d1xu7d_: 1xu7 D: [116051]
      complexed with cps, ndp
  2. Domain(s) for 1xu9:
    1. 1826967Domain d1xu9a_: 1xu9 A: [116052]
      complexed with cps, mes, ndp
    2. 1826968Domain d1xu9b_: 1xu9 B: [116053]
      complexed with cps, mes, ndp
    3. 1826969Domain d1xu9c_: 1xu9 C: [116054]
      complexed with cps, mes, ndp
    4. 1826970Domain d1xu9d_: 1xu9 D: [116055]
      complexed with cps, mes, ndp
  3. Domain(s) for 2bel:
    1. 1826983Domain d2bela_: 2bel A: [116694]
      complexed with cbo, cl, nap
    2. 1826984Domain d2belb_: 2bel B: [116695]
      complexed with cbo, cl, nap
    3. 1826985Domain d2belc_: 2bel C: [116696]
      complexed with cbo, cl, nap
    4. 1826986Domain d2beld_: 2bel D: [116697]
      complexed with cbo, cl, nap
  4. Domain(s) for 2ilt:
  5. Domain(s) for 2irw:
    1. 1827062Domain d2irwa_: 2irw A: [137593]
      automated match to d2irwa1
      complexed with nap, nn4
    2. 1827063Domain d2irwb_: 2irw B: [137594]
      automated match to d2irwb1
      complexed with nap, nn4
    3. 1827064Domain d2irwc_: 2irw C: [137595]
      automated match to d2irwd1
      complexed with nap, nn4
    4. 1827065Domain d2irwd_: 2irw D: [137596]
      automated match to d2irwd1
      complexed with nap, nn4
    5. 1827066Domain d2irwe_: 2irw E: [137597]
      automated match to d2irwd1
      complexed with nap, nn4
    6. 1827067Domain d2irwf_: 2irw F: [137598]
      automated match to d2irwf1
      complexed with nap, nn4
    7. 1827068Domain d2irwg_: 2irw G: [137599]
      automated match to d2irwg1
      complexed with nap, nn4
    8. 1827069Domain d2irwh_: 2irw H: [137600]
      automated match to d2irwg1
      complexed with nap, nn4
  6. Domain(s) for 2rbe:
    1. 1826979Domain d2rbea_: 2rbe A: [151846]
      automated match to d1xu9a_
      complexed with ndp, zmg
    2. 1826980Domain d2rbeb_: 2rbe B: [151847]
      automated match to d1xu9a_
      complexed with ndp, zmg
    3. 1826981Domain d2rbec_: 2rbe C: [151848]
      automated match to d1xu9a_
      complexed with ndp, zmg
    4. 1826982Domain d2rbed_: 2rbe D: [151849]
      automated match to d1xu9a_
      complexed with ndp, zmg
  7. Domain(s) for 3byz:
    1. 1827048Domain d3byza_: 3byz A: [155734]
      automated match to d1xu9a_
      complexed with h11, ndp
    2. 1827049Domain d3byzb_: 3byz B: [155735]
      automated match to d1xu9a_
      complexed with h11, ndp
    3. 1827050Domain d3byzc_: 3byz C: [155736]
      automated match to d1xu9a_
      complexed with h11, ndp
    4. 1827051Domain d3byzd_: 3byz D: [155737]
      automated match to d1xu9a_
      complexed with h11, ndp
  8. Domain(s) for 3bzu:
    1. 1826999Domain d3bzua_: 3bzu A: [155788]
      automated match to d1xu9a_
      complexed with a21, nap
    2. 1827000Domain d3bzub_: 3bzu B: [155789]
      automated match to d1xu9a_
      complexed with a21, nap
    3. 1827001Domain d3bzuc_: 3bzu C: [155790]
      automated match to d1xu9a_
      complexed with a21, nap
    4. 1827002Domain d3bzud_: 3bzu D: [155791]
      automated match to d1xu9a_
      complexed with a21, nap
  9. Domain(s) for 3ch6:
    1. 1827005Domain d3ch6a_: 3ch6 A: [173241]
      automated match to d1xu9a_
      complexed with 311, nap; mutant
    2. 1827006Domain d3ch6b_: 3ch6 B: [173242]
      automated match to d1xu9a_
      complexed with 311, nap; mutant
    3. 1827007Domain d3ch6d_: 3ch6 D: [173243]
      automated match to d1xu9a_
      complexed with 311, nap; mutant
    4. 1827008Domain d3ch6e_: 3ch6 E: [173244]
      automated match to d1xu9a_
      complexed with 311, nap; mutant
  10. Domain(s) for 3czr:
    1. 1827016Domain d3czra_: 3czr A: [157154]
      automated match to d1xu9a_
      complexed with 3cz, cps, nap
    2. 1827017Domain d3czrb_: 3czr B: [157155]
      automated match to d1xu9a_
      complexed with 3cz, cps, nap
  11. Domain(s) for 3d3e:
    1. 1827042Domain d3d3ea_: 3d3e A: [157280]
      automated match to d1xu9a_
      complexed with d3e, nap
    2. 1827043Domain d3d3eb_: 3d3e B: [157281]
      automated match to d1xu9a_
      complexed with d3e, nap
    3. 1827044Domain d3d3ec_: 3d3e C: [157282]
      automated match to d1xu9a_
      complexed with d3e, nap
    4. 1827045Domain d3d3ed_: 3d3e D: [157283]
      automated match to d1xu9a_
      complexed with d3e, nap
  12. Domain(s) for 3d4n:
    1. 1827030Domain d3d4na_: 3d4n A: [157296]
      automated match to d1xu9a_
      complexed with d4n, nap
    2. 1827031Domain d3d4nb_: 3d4n B: [157297]
      automated match to d1xu9a_
      complexed with d4n, nap
    3. 1827032Domain d3d4nc_: 3d4n C: [157298]
      automated match to d1xu9a_
      complexed with d4n, nap
    4. 1827033Domain d3d4nd_: 3d4n D: [157299]
      automated match to d1xu9a_
      complexed with d4n, nap
  13. Domain(s) for 3d5q:
    1. 1827038Domain d3d5qa_: 3d5q A: [157399]
      automated match to d1xu9a_
      complexed with nap, t30
    2. 1827039Domain d3d5qb_: 3d5q B: [157400]
      automated match to d1xu9a_
      complexed with nap, t30
    3. 1827040Domain d3d5qc_: 3d5q C: [157401]
      automated match to d1xu9a_
      complexed with nap, t30
    4. 1827041Domain d3d5qd_: 3d5q D: [157402]
      automated match to d1xu9a_
      complexed with nap, t30
  14. Domain(s) for 3ey4:
    1. 1827058Domain d3ey4a_: 3ey4 A: [245988]
      automated match to d3pdjb_
      complexed with 352, ndp
    2. 1827059Domain d3ey4b_: 3ey4 B: [245989]
      automated match to d3pdjb_
      complexed with 352, ndp
    3. 1827060Domain d3ey4c_: 3ey4 C: [245990]
      automated match to d3pdjb_
      complexed with 352, ndp
    4. 1827061Domain d3ey4d_: 3ey4 D: [245991]
      automated match to d3pdjb_
      complexed with 352, ndp
  15. Domain(s) for 3fco:
    1. 1827046Domain d3fcoa_: 3fco A: [175688]
      automated match to d1xu9a_
      complexed with iig, nap
    2. 1827047Domain d3fcob_: 3fco B: [175689]
      automated match to d1xu9a_
      complexed with iig, nap
  16. Domain(s) for 3frj:
    1. 1827003Domain d3frja_: 3frj A: [176002]
      automated match to d1xu9a_
      complexed with a49, nap
    2. 1827004Domain d3frjb_: 3frj B: [176003]
      automated match to d1xu9a_
      complexed with a49, nap
  17. Domain(s) for 3h6k:
    1. 1826995Domain d3h6ka_: 3h6k A: [177284]
      automated match to d1xu9a_
      complexed with 33t, nap
    2. 1826996Domain d3h6kb_: 3h6k B: [177285]
      automated match to d1xu9a_
      complexed with 33t, nap
    3. 1826997Domain d3h6kc_: 3h6k C: [177286]
      automated match to d1xu9a_
      complexed with 33t, nap
    4. 1826998Domain d3h6kd_: 3h6k D: [177287]
      automated match to d1xu9a_
      complexed with 33t, nap
  18. Domain(s) for 3hfg:
    1. 1827018Domain d3hfga_: 3hfg A: [177530]
      automated match to d1xu9a_
      complexed with 17r, nap
    2. 1827019Domain d3hfgb_: 3hfg B: [177531]
      automated match to d1xu9a_
      complexed with 17r, nap
    3. 1827020Domain d3hfgc_: 3hfg C: [177532]
      automated match to d1xu9a_
      complexed with 17r, nap
    4. 1827021Domain d3hfgd_: 3hfg D: [177533]
      automated match to d1xu9a_
      complexed with 17r, nap
  19. Domain(s) for 3oq1:
    1. 1827052Domain d3oq1a_: 3oq1 A: [214474]
      automated match to d1xu9a_
      complexed with 3oq, nap
    2. 1827053Domain d3oq1b_: 3oq1 B: [214475]
      automated match to d1xu9a_
      complexed with 3oq, nap
    3. 1827054Domain d3oq1c_: 3oq1 C: [214476]
      automated match to d1xu9a_
      complexed with 3oq, nap
    4. 1827055Domain d3oq1d_: 3oq1 D: [214477]
      automated match to d1xu9a_
      complexed with 3oq, nap
  20. Domain(s) for 3pdj:
    1. 1827009Domain d3pdja_: 3pdj A: [183673]
      automated match to d1xu9b_
      complexed with 3pj, nap
    2. 1827010Domain d3pdjb_: 3pdj B: [183674]
      automated match to d1xu9b_
      complexed with 3pj, nap
  21. Domain(s) for 3qqp:
    1. 1827012Domain d3qqpa_: 3qqp A: [215369]
      automated match to d1xu9b_
      complexed with ndp, s05
    2. 1827013Domain d3qqpb_: 3qqp B: [215370]
      automated match to d1xu9b_
      complexed with ndp, s05
    3. 1827014Domain d3qqpc_: 3qqp C: [215371]
      automated match to d1xu9b_
      complexed with ndp, s05
    4. 1827015Domain d3qqpd_: 3qqp D: [215372]
      automated match to d1xu9b_
      complexed with ndp, s05
  22. Domain(s) for 3tfq:
    1. 1826971Domain d3tfqa_: 3tfq A: [185814]
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant
    2. 1826972Domain d3tfqb_: 3tfq B: [185815]
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant
    3. 1826973Domain d3tfqd_: 3tfq D: [185816]
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant
    4. 1826974Domain d3tfqe_: 3tfq E: [185817]
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant
  23. Domain(s) for 4hfr:
    1. 1827056Domain d4hfra_: 4hfr A: [222558]
      automated match to d3pdjb_
      complexed with 14m, nap
    2. 1827057Domain d4hfrb_: 4hfr B: [222559]
      automated match to d3pdjb_
      complexed with 14m, nap
  24. Domain(s) for 4hx5:
    1. 1826987Domain d4hx5a_: 4hx5 A: [197024]
      automated match to d3pdjb_
      complexed with 19v, ndp
    2. 1826988Domain d4hx5b_: 4hx5 B: [197314]
      automated match to d3pdjb_
      complexed with 19v, ndp
    3. 1826989Domain d4hx5c_: 4hx5 C: [197313]
      automated match to d3pdjb_
      complexed with 19v, ndp
    4. 1826990Domain d4hx5d_: 4hx5 D: [202508]
      automated match to d1xu9b_
      complexed with 19v, ndp
  25. Domain(s) for 4iju:
    1. 1827022Domain d4ijua_: 4iju A: [256781]
      automated match to d3tfqb_
      complexed with 1eo, cl, nap; mutant
    2. 1827023Domain d4ijub_: 4iju B: [262723]
      automated match to d3tfqb_
      complexed with 1eo, cl, nap; mutant
    3. 1827024Domain d4ijud_: 4iju D: [258662]
      automated match to d3tfqb_
      complexed with 1eo, cl, nap; mutant
    4. 1827025Domain d4ijue_: 4iju E: [262724]
      automated match to d3tfqb_
      complexed with 1eo, cl, nap; mutant
  26. Domain(s) for 4ijv:
    1. 1827026Domain d4ijva_: 4ijv A: [266432]
      automated match to d3tfqb_
      complexed with 1en, nap; mutant
    2. 1827027Domain d4ijvb_: 4ijv B: [266433]
      automated match to d3tfqb_
      complexed with 1en, nap; mutant
    3. 1827028Domain d4ijvd_: 4ijv D: [266434]
      automated match to d3tfqb_
      complexed with 1en, nap; mutant
    4. 1827029Domain d4ijve_: 4ijv E: [266435]
      automated match to d3tfqb_
      complexed with 1en, nap; mutant
  27. Domain(s) for 4ijw:
    1. 1827034Domain d4ijwa_: 4ijw A: [266436]
      automated match to d3tfqb_
      complexed with 1eq, nap; mutant
    2. 1827035Domain d4ijwb_: 4ijw B: [266437]
      automated match to d3tfqb_
      complexed with 1eq, nap; mutant
    3. 1827036Domain d4ijwd_: 4ijw D: [266438]
      automated match to d3tfqb_
      complexed with 1eq, nap; mutant
    4. 1827037Domain d4ijwe_: 4ijw E: [266439]
      automated match to d3tfqb_
      complexed with 1eq, nap; mutant
  28. Domain(s) for 4k1l:
    1. 1826991Domain d4k1la_: 4k1l A: [238381]
      automated match to d1xu9a_
      complexed with ndp, sff
    2. 1826992Domain d4k1lb_: 4k1l B: [238387]
      automated match to d1xu9b_
      complexed with ndp, sff
    3. 1826993Domain d4k1lc_: 4k1l C: [238389]
      automated match to d1xu9a_
      complexed with ndp, sff
    4. 1826994Domain d4k1ld_: 4k1l D: [238390]
      automated match to d1xu9b_
      complexed with ndp, sff
  29. Domain(s) for 4p38:
    1. 1827070Domain d4p38a_: 4p38 A: [257395]
      automated match to d4bb6a_
      complexed with 21t, cl, ndp
    2. 1827071Domain d4p38b_: 4p38 B: [260937]
      automated match to d4bb6a_
      complexed with 21t, cl, ndp

More info for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1: