Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOPe 2.02
  2. 1143363Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 1150729Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 1150730Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 1151047Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 1151074Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
  7. 1151090Species Human (Homo sapiens) [TaxId:9606] [117424] (20 PDB entries)
    Uniprot P28845

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 1xu7:
    1. 1151099Domain d1xu7a_: 1xu7 A: [116048]
      complexed with cps, ndp
    2. 1151100Domain d1xu7b_: 1xu7 B: [116049]
      complexed with cps, ndp
    3. 1151101Domain d1xu7c_: 1xu7 C: [116050]
      complexed with cps, ndp
    4. 1151102Domain d1xu7d_: 1xu7 D: [116051]
      complexed with cps, ndp
  2. Domain(s) for 1xu9:
    1. 1151091Domain d1xu9a_: 1xu9 A: [116052]
      complexed with cps, mes, ndp
    2. 1151092Domain d1xu9b_: 1xu9 B: [116053]
      complexed with cps, mes, ndp
    3. 1151093Domain d1xu9c_: 1xu9 C: [116054]
      complexed with cps, mes, ndp
    4. 1151094Domain d1xu9d_: 1xu9 D: [116055]
      complexed with cps, mes, ndp
  3. Domain(s) for 2bel:
    1. 1151107Domain d2bela_: 2bel A: [116694]
      complexed with cbo, cl, nap
    2. 1151108Domain d2belb_: 2bel B: [116695]
      complexed with cbo, cl, nap
    3. 1151109Domain d2belc_: 2bel C: [116696]
      complexed with cbo, cl, nap
    4. 1151110Domain d2beld_: 2bel D: [116697]
      complexed with cbo, cl, nap
  4. Domain(s) for 2ilt:
  5. Domain(s) for 2irw:
    1. 1151155Domain d2irwa1: 2irw A:26-289 [137593]
      automatically matched to d1xu9b_
      complexed with nap, nn4
    2. 1151156Domain d2irwb1: 2irw B:26-289 [137594]
      automatically matched to d1xu9b_
      complexed with nap, nn4
    3. 1151157Domain d2irwc1: 2irw C:26-282 [137595]
      automatically matched to d1xu9b_
      complexed with nap, nn4
    4. 1151158Domain d2irwd1: 2irw D:26-289 [137596]
      automatically matched to d1xu9b_
      complexed with nap, nn4
    5. 1151159Domain d2irwe1: 2irw E:26-282 [137597]
      automatically matched to d1xu9b_
      complexed with nap, nn4
    6. 1151160Domain d2irwf1: 2irw F:26-289 [137598]
      automatically matched to d1xu9b_
      complexed with nap, nn4
    7. 1151161Domain d2irwg1: 2irw G:26-289 [137599]
      automatically matched to d1xu9b_
      complexed with nap, nn4
    8. 1151162Domain d2irwh1: 2irw H:26-289 [137600]
      automatically matched to d1xu9b_
      complexed with nap, nn4
  6. Domain(s) for 2rbe:
    1. 1151103Domain d2rbea_: 2rbe A: [151846]
      automated match to d1xu9a_
      complexed with ndp, zmg
    2. 1151104Domain d2rbeb_: 2rbe B: [151847]
      automated match to d1xu9a_
      complexed with ndp, zmg
    3. 1151105Domain d2rbec_: 2rbe C: [151848]
      automated match to d1xu9a_
      complexed with ndp, zmg
    4. 1151106Domain d2rbed_: 2rbe D: [151849]
      automated match to d1xu9a_
      complexed with ndp, zmg
  7. Domain(s) for 3byz:
    1. 1151151Domain d3byza_: 3byz A: [155734]
      automated match to d1xu9a_
      complexed with h11, ndp
    2. 1151152Domain d3byzb_: 3byz B: [155735]
      automated match to d1xu9a_
      complexed with h11, ndp
    3. 1151153Domain d3byzc_: 3byz C: [155736]
      automated match to d1xu9a_
      complexed with h11, ndp
    4. 1151154Domain d3byzd_: 3byz D: [155737]
      automated match to d1xu9a_
      complexed with h11, ndp
  8. Domain(s) for 3bzu:
    1. 1151118Domain d3bzua_: 3bzu A: [155788]
      automated match to d1xu9a_
      complexed with a21, nap
    2. 1151119Domain d3bzub_: 3bzu B: [155789]
      automated match to d1xu9a_
      complexed with a21, nap
    3. 1151120Domain d3bzuc_: 3bzu C: [155790]
      automated match to d1xu9a_
      complexed with a21, nap
    4. 1151121Domain d3bzud_: 3bzu D: [155791]
      automated match to d1xu9a_
      complexed with a21, nap
  9. Domain(s) for 3ch6:
    1. 1151124Domain d3ch6a_: 3ch6 A: [173241]
      automated match to d1xu9a_
      complexed with 311, nap; mutant
    2. 1151125Domain d3ch6b_: 3ch6 B: [173242]
      automated match to d1xu9a_
      complexed with 311, nap; mutant
    3. 1151126Domain d3ch6d_: 3ch6 D: [173243]
      automated match to d1xu9a_
      complexed with 311, nap; mutant
    4. 1151127Domain d3ch6e_: 3ch6 E: [173244]
      automated match to d1xu9a_
      complexed with 311, nap; mutant
  10. Domain(s) for 3czr:
    1. 1151131Domain d3czra_: 3czr A: [157154]
      automated match to d1xu9a_
      complexed with 3cz, cps, nap
    2. 1151132Domain d3czrb_: 3czr B: [157155]
      automated match to d1xu9a_
      complexed with 3cz, cps, nap
  11. Domain(s) for 3d3e:
    1. 1151145Domain d3d3ea_: 3d3e A: [157280]
      automated match to d1xu9a_
      complexed with d3e, nap
    2. 1151146Domain d3d3eb_: 3d3e B: [157281]
      automated match to d1xu9a_
      complexed with d3e, nap
    3. 1151147Domain d3d3ec_: 3d3e C: [157282]
      automated match to d1xu9a_
      complexed with d3e, nap
    4. 1151148Domain d3d3ed_: 3d3e D: [157283]
      automated match to d1xu9a_
      complexed with d3e, nap
  12. Domain(s) for 3d4n:
    1. 1151137Domain d3d4na_: 3d4n A: [157296]
      automated match to d1xu9a_
      complexed with d4n, nap
    2. 1151138Domain d3d4nb_: 3d4n B: [157297]
      automated match to d1xu9a_
      complexed with d4n, nap
    3. 1151139Domain d3d4nc_: 3d4n C: [157298]
      automated match to d1xu9a_
      complexed with d4n, nap
    4. 1151140Domain d3d4nd_: 3d4n D: [157299]
      automated match to d1xu9a_
      complexed with d4n, nap
  13. Domain(s) for 3d5q:
    1. 1151141Domain d3d5qa_: 3d5q A: [157399]
      automated match to d1xu9a_
      complexed with nap, t30
    2. 1151142Domain d3d5qb_: 3d5q B: [157400]
      automated match to d1xu9a_
      complexed with nap, t30
    3. 1151143Domain d3d5qc_: 3d5q C: [157401]
      automated match to d1xu9a_
      complexed with nap, t30
    4. 1151144Domain d3d5qd_: 3d5q D: [157402]
      automated match to d1xu9a_
      complexed with nap, t30
  14. Domain(s) for 3fco:
    1. 1151149Domain d3fcoa_: 3fco A: [175688]
      automated match to d1xu9a_
      complexed with iig, nap
    2. 1151150Domain d3fcob_: 3fco B: [175689]
      automated match to d1xu9a_
      complexed with iig, nap
  15. Domain(s) for 3frj:
    1. 1151122Domain d3frja_: 3frj A: [176002]
      automated match to d1xu9a_
      complexed with a49, nap
    2. 1151123Domain d3frjb_: 3frj B: [176003]
      automated match to d1xu9a_
      complexed with a49, nap
  16. Domain(s) for 3h6k:
    1. 1151114Domain d3h6ka_: 3h6k A: [177284]
      automated match to d1xu9a_
      complexed with 33t, nap
    2. 1151115Domain d3h6kb_: 3h6k B: [177285]
      automated match to d1xu9a_
      complexed with 33t, nap
    3. 1151116Domain d3h6kc_: 3h6k C: [177286]
      automated match to d1xu9a_
      complexed with 33t, nap
    4. 1151117Domain d3h6kd_: 3h6k D: [177287]
      automated match to d1xu9a_
      complexed with 33t, nap
  17. Domain(s) for 3hfg:
    1. 1151133Domain d3hfga_: 3hfg A: [177530]
      automated match to d1xu9a_
      complexed with 17r, nap
    2. 1151134Domain d3hfgb_: 3hfg B: [177531]
      automated match to d1xu9a_
      complexed with 17r, nap
    3. 1151135Domain d3hfgc_: 3hfg C: [177532]
      automated match to d1xu9a_
      complexed with 17r, nap
    4. 1151136Domain d3hfgd_: 3hfg D: [177533]
      automated match to d1xu9a_
      complexed with 17r, nap
  18. Domain(s) for 3pdj:
    1. 1151128Domain d3pdja_: 3pdj A: [183673]
      automated match to d1xu9b_
      complexed with 3pj, nap
    2. 1151129Domain d3pdjb_: 3pdj B: [183674]
      automated match to d1xu9b_
      complexed with 3pj, nap
  19. Domain(s) for 3tfq:
    1. 1151095Domain d3tfqa_: 3tfq A: [185814]
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant
    2. 1151096Domain d3tfqb_: 3tfq B: [185815]
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant
    3. 1151097Domain d3tfqd_: 3tfq D: [185816]
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant
    4. 1151098Domain d3tfqe_: 3tfq E: [185817]
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant
  20. Domain(s) for 4hx5:
    1. 1151111Domain d4hx5a_: 4hx5 A: [197024]
      automated match to d3pdjb_
      complexed with 19v, ndp
    2. 1151112Domain d4hx5b_: 4hx5 B: [197314]
      automated match to d3pdjb_
      complexed with 19v, ndp
    3. 1151113Domain d4hx5c_: 4hx5 C: [197313]
      automated match to d3pdjb_
      complexed with 19v, ndp

More info for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1: