Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOPe 2.01
  2. 968085Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 975118Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 975119Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 975436Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 975463Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
  7. 975479Species Human (Homo sapiens) [TaxId:9606] [117424] (19 PDB entries)
    Uniprot P28845

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 1xu7:
    1. 975488Domain d1xu7a_: 1xu7 A: [116048]
      complexed with cps, ndp
    2. 975489Domain d1xu7b_: 1xu7 B: [116049]
      complexed with cps, ndp
    3. 975490Domain d1xu7c_: 1xu7 C: [116050]
      complexed with cps, ndp
    4. 975491Domain d1xu7d_: 1xu7 D: [116051]
      complexed with cps, ndp
  2. Domain(s) for 1xu9:
    1. 975480Domain d1xu9a_: 1xu9 A: [116052]
      complexed with cps, mes, ndp
    2. 975481Domain d1xu9b_: 1xu9 B: [116053]
      complexed with cps, mes, ndp
    3. 975482Domain d1xu9c_: 1xu9 C: [116054]
      complexed with cps, mes, ndp
    4. 975483Domain d1xu9d_: 1xu9 D: [116055]
      complexed with cps, mes, ndp
  3. Domain(s) for 2bel:
    1. 975496Domain d2bela_: 2bel A: [116694]
      complexed with cbo, cl, nap
    2. 975497Domain d2belb_: 2bel B: [116695]
      complexed with cbo, cl, nap
    3. 975498Domain d2belc_: 2bel C: [116696]
      complexed with cbo, cl, nap
    4. 975499Domain d2beld_: 2bel D: [116697]
      complexed with cbo, cl, nap
  4. Domain(s) for 2ilt:
  5. Domain(s) for 2irw:
    1. 975541Domain d2irwa1: 2irw A:26-289 [137593]
      automatically matched to d1xu9b_
      complexed with nap, nn4
    2. 975542Domain d2irwb1: 2irw B:26-289 [137594]
      automatically matched to d1xu9b_
      complexed with nap, nn4
    3. 975543Domain d2irwc1: 2irw C:26-282 [137595]
      automatically matched to d1xu9b_
      complexed with nap, nn4
    4. 975544Domain d2irwd1: 2irw D:26-289 [137596]
      automatically matched to d1xu9b_
      complexed with nap, nn4
    5. 975545Domain d2irwe1: 2irw E:26-282 [137597]
      automatically matched to d1xu9b_
      complexed with nap, nn4
    6. 975546Domain d2irwf1: 2irw F:26-289 [137598]
      automatically matched to d1xu9b_
      complexed with nap, nn4
    7. 975547Domain d2irwg1: 2irw G:26-289 [137599]
      automatically matched to d1xu9b_
      complexed with nap, nn4
    8. 975548Domain d2irwh1: 2irw H:26-289 [137600]
      automatically matched to d1xu9b_
      complexed with nap, nn4
  6. Domain(s) for 2rbe:
    1. 975492Domain d2rbea_: 2rbe A: [151846]
      automated match to d1xu9a_
      complexed with ndp, zmg
    2. 975493Domain d2rbeb_: 2rbe B: [151847]
      automated match to d1xu9a_
      complexed with ndp, zmg
    3. 975494Domain d2rbec_: 2rbe C: [151848]
      automated match to d1xu9a_
      complexed with ndp, zmg
    4. 975495Domain d2rbed_: 2rbe D: [151849]
      automated match to d1xu9a_
      complexed with ndp, zmg
  7. Domain(s) for 3byz:
    1. 975537Domain d3byza_: 3byz A: [155734]
      automated match to d1xu9a_
      complexed with h11, ndp
    2. 975538Domain d3byzb_: 3byz B: [155735]
      automated match to d1xu9a_
      complexed with h11, ndp
    3. 975539Domain d3byzc_: 3byz C: [155736]
      automated match to d1xu9a_
      complexed with h11, ndp
    4. 975540Domain d3byzd_: 3byz D: [155737]
      automated match to d1xu9a_
      complexed with h11, ndp
  8. Domain(s) for 3bzu:
    1. 975504Domain d3bzua_: 3bzu A: [155788]
      automated match to d1xu9a_
      complexed with a21, nap
    2. 975505Domain d3bzub_: 3bzu B: [155789]
      automated match to d1xu9a_
      complexed with a21, nap
    3. 975506Domain d3bzuc_: 3bzu C: [155790]
      automated match to d1xu9a_
      complexed with a21, nap
    4. 975507Domain d3bzud_: 3bzu D: [155791]
      automated match to d1xu9a_
      complexed with a21, nap
  9. Domain(s) for 3ch6:
    1. 975510Domain d3ch6a_: 3ch6 A: [173241]
      automated match to d1xu9a_
      complexed with 311, nap; mutant
    2. 975511Domain d3ch6b_: 3ch6 B: [173242]
      automated match to d1xu9a_
      complexed with 311, nap; mutant
    3. 975512Domain d3ch6d_: 3ch6 D: [173243]
      automated match to d1xu9a_
      complexed with 311, nap; mutant
    4. 975513Domain d3ch6e_: 3ch6 E: [173244]
      automated match to d1xu9a_
      complexed with 311, nap; mutant
  10. Domain(s) for 3czr:
    1. 975517Domain d3czra_: 3czr A: [157154]
      automated match to d1xu9a_
      complexed with 3cz, cps, nap
    2. 975518Domain d3czrb_: 3czr B: [157155]
      automated match to d1xu9a_
      complexed with 3cz, cps, nap
  11. Domain(s) for 3d3e:
    1. 975531Domain d3d3ea_: 3d3e A: [157280]
      automated match to d1xu9a_
      complexed with d3e, nap
    2. 975532Domain d3d3eb_: 3d3e B: [157281]
      automated match to d1xu9a_
      complexed with d3e, nap
    3. 975533Domain d3d3ec_: 3d3e C: [157282]
      automated match to d1xu9a_
      complexed with d3e, nap
    4. 975534Domain d3d3ed_: 3d3e D: [157283]
      automated match to d1xu9a_
      complexed with d3e, nap
  12. Domain(s) for 3d4n:
    1. 975523Domain d3d4na_: 3d4n A: [157296]
      automated match to d1xu9a_
      complexed with d4n, nap
    2. 975524Domain d3d4nb_: 3d4n B: [157297]
      automated match to d1xu9a_
      complexed with d4n, nap
    3. 975525Domain d3d4nc_: 3d4n C: [157298]
      automated match to d1xu9a_
      complexed with d4n, nap
    4. 975526Domain d3d4nd_: 3d4n D: [157299]
      automated match to d1xu9a_
      complexed with d4n, nap
  13. Domain(s) for 3d5q:
    1. 975527Domain d3d5qa_: 3d5q A: [157399]
      automated match to d1xu9a_
      complexed with nap, t30
    2. 975528Domain d3d5qb_: 3d5q B: [157400]
      automated match to d1xu9a_
      complexed with nap, t30
    3. 975529Domain d3d5qc_: 3d5q C: [157401]
      automated match to d1xu9a_
      complexed with nap, t30
    4. 975530Domain d3d5qd_: 3d5q D: [157402]
      automated match to d1xu9a_
      complexed with nap, t30
  14. Domain(s) for 3fco:
    1. 975535Domain d3fcoa_: 3fco A: [175688]
      automated match to d1xu9a_
      complexed with iig, nap
    2. 975536Domain d3fcob_: 3fco B: [175689]
      automated match to d1xu9a_
      complexed with iig, nap
  15. Domain(s) for 3frj:
    1. 975508Domain d3frja_: 3frj A: [176002]
      automated match to d1xu9a_
      complexed with a49, nap
    2. 975509Domain d3frjb_: 3frj B: [176003]
      automated match to d1xu9a_
      complexed with a49, nap
  16. Domain(s) for 3h6k:
    1. 975500Domain d3h6ka_: 3h6k A: [177284]
      automated match to d1xu9a_
      complexed with 33t, nap
    2. 975501Domain d3h6kb_: 3h6k B: [177285]
      automated match to d1xu9a_
      complexed with 33t, nap
    3. 975502Domain d3h6kc_: 3h6k C: [177286]
      automated match to d1xu9a_
      complexed with 33t, nap
    4. 975503Domain d3h6kd_: 3h6k D: [177287]
      automated match to d1xu9a_
      complexed with 33t, nap
  17. Domain(s) for 3hfg:
    1. 975519Domain d3hfga_: 3hfg A: [177530]
      automated match to d1xu9a_
      complexed with 17r, nap
    2. 975520Domain d3hfgb_: 3hfg B: [177531]
      automated match to d1xu9a_
      complexed with 17r, nap
    3. 975521Domain d3hfgc_: 3hfg C: [177532]
      automated match to d1xu9a_
      complexed with 17r, nap
    4. 975522Domain d3hfgd_: 3hfg D: [177533]
      automated match to d1xu9a_
      complexed with 17r, nap
  18. Domain(s) for 3pdj:
    1. 975514Domain d3pdja_: 3pdj A: [183673]
      automated match to d1xu9b_
      complexed with 3pj, nap
    2. 975515Domain d3pdjb_: 3pdj B: [183674]
      automated match to d1xu9b_
      complexed with 3pj, nap
  19. Domain(s) for 3tfq:
    1. 975484Domain d3tfqa_: 3tfq A: [185814]
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant
    2. 975485Domain d3tfqb_: 3tfq B: [185815]
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant
    3. 975486Domain d3tfqd_: 3tfq D: [185816]
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant
    4. 975487Domain d3tfqe_: 3tfq E: [185817]
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant

More info for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1: