Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2090218Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2090219Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2090553Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 protein domains)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 2090580Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
  7. 2090596Species Human (Homo sapiens) [TaxId:9606] [117424] (29 PDB entries)
    Uniprot P28845

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 1xu7:
    1. 2090605Domain d1xu7a1: 1xu7 A:24-283 [116048]
      Other proteins in same PDB: d1xu7a2, d1xu7b2, d1xu7c2, d1xu7d2
      complexed with cps, ndp
    2. 2090606Domain d1xu7b1: 1xu7 B:24-282 [116049]
      Other proteins in same PDB: d1xu7a2, d1xu7b2, d1xu7c2, d1xu7d2
      complexed with cps, ndp
    3. 2090607Domain d1xu7c1: 1xu7 C:24-282 [116050]
      Other proteins in same PDB: d1xu7a2, d1xu7b2, d1xu7c2, d1xu7d2
      complexed with cps, ndp
    4. 2090608Domain d1xu7d1: 1xu7 D:24-281 [116051]
      Other proteins in same PDB: d1xu7a2, d1xu7b2, d1xu7c2, d1xu7d2
      complexed with cps, ndp
  2. Domain(s) for 1xu9:
    1. 2090597Domain d1xu9a1: 1xu9 A:24-289 [116052]
      Other proteins in same PDB: d1xu9a2, d1xu9b2, d1xu9c2, d1xu9d2
      complexed with cps, mes, ndp
    2. 2090598Domain d1xu9b1: 1xu9 B:24-289 [116053]
      Other proteins in same PDB: d1xu9a2, d1xu9b2, d1xu9c2, d1xu9d2
      complexed with cps, mes, ndp
    3. 2090599Domain d1xu9c1: 1xu9 C:24-281 [116054]
      Other proteins in same PDB: d1xu9a2, d1xu9b2, d1xu9c2, d1xu9d2
      complexed with cps, mes, ndp
    4. 2090600Domain d1xu9d1: 1xu9 D:24-281 [116055]
      Other proteins in same PDB: d1xu9a2, d1xu9b2, d1xu9c2, d1xu9d2
      complexed with cps, mes, ndp
  3. Domain(s) for 2bel:
    1. 2090613Domain d2bela_: 2bel A: [116694]
      Other proteins in same PDB: d2belc2, d2beld2
      complexed with cbo, cl, nap
    2. 2090614Domain d2belb_: 2bel B: [116695]
      Other proteins in same PDB: d2belc2, d2beld2
      complexed with cbo, cl, nap
    3. 2090615Domain d2belc1: 2bel C:26-271 [116696]
      Other proteins in same PDB: d2belc2, d2beld2
      complexed with cbo, cl, nap
    4. 2090616Domain d2beld1: 2bel D:26-277 [116697]
      Other proteins in same PDB: d2belc2, d2beld2
      complexed with cbo, cl, nap
  4. Domain(s) for 2ilt:
  5. Domain(s) for 2irw:
    1. 2090692Domain d2irwa_: 2irw A: [137593]
      automated match to d2irwa1
      complexed with nap, nn4
    2. 2090693Domain d2irwb_: 2irw B: [137594]
      automated match to d2irwb1
      complexed with nap, nn4
    3. 2090694Domain d2irwc_: 2irw C: [137595]
      automated match to d2irwd1
      complexed with nap, nn4
    4. 2090695Domain d2irwd_: 2irw D: [137596]
      automated match to d2irwd1
      complexed with nap, nn4
    5. 2090696Domain d2irwe_: 2irw E: [137597]
      automated match to d2irwd1
      complexed with nap, nn4
    6. 2090697Domain d2irwf_: 2irw F: [137598]
      automated match to d2irwf1
      complexed with nap, nn4
    7. 2090698Domain d2irwg_: 2irw G: [137599]
      automated match to d2irwg1
      complexed with nap, nn4
    8. 2090699Domain d2irwh_: 2irw H: [137600]
      automated match to d2irwg1
      complexed with nap, nn4
  6. Domain(s) for 2rbe:
    1. 2090609Domain d2rbea_: 2rbe A: [151846]
      automated match to d1xu9a_
      complexed with ndp, zmg
    2. 2090610Domain d2rbeb_: 2rbe B: [151847]
      automated match to d1xu9a_
      complexed with ndp, zmg
    3. 2090611Domain d2rbec_: 2rbe C: [151848]
      automated match to d1xu9a_
      complexed with ndp, zmg
    4. 2090612Domain d2rbed_: 2rbe D: [151849]
      automated match to d1xu9a_
      complexed with ndp, zmg
  7. Domain(s) for 3byz:
    1. 2090678Domain d3byza_: 3byz A: [155734]
      automated match to d1xu9a_
      complexed with h11, ndp
    2. 2090679Domain d3byzb_: 3byz B: [155735]
      automated match to d1xu9a_
      complexed with h11, ndp
    3. 2090680Domain d3byzc_: 3byz C: [155736]
      automated match to d1xu9a_
      complexed with h11, ndp
    4. 2090681Domain d3byzd_: 3byz D: [155737]
      automated match to d1xu9a_
      complexed with h11, ndp
  8. Domain(s) for 3bzu:
    1. 2090629Domain d3bzua_: 3bzu A: [155788]
      Other proteins in same PDB: d3bzub3
      automated match to d1xu9a_
      complexed with a21, nap
    2. 2090630Domain d3bzub2: 3bzu B:24-283 [155789]
      Other proteins in same PDB: d3bzub3
      automated match to d1xu9a_
      complexed with a21, nap
    3. 2090631Domain d3bzuc_: 3bzu C: [155790]
      Other proteins in same PDB: d3bzub3
      automated match to d1xu9a_
      complexed with a21, nap
    4. 2090632Domain d3bzud_: 3bzu D: [155791]
      Other proteins in same PDB: d3bzub3
      automated match to d1xu9a_
      complexed with a21, nap
  9. Domain(s) for 3ch6:
    1. 2090635Domain d3ch6a_: 3ch6 A: [173241]
      Other proteins in same PDB: d3ch6b2, d3ch6d2
      automated match to d1xu9a_
      complexed with 311, nap; mutant
    2. 2090636Domain d3ch6b1: 3ch6 B:24-288 [173242]
      Other proteins in same PDB: d3ch6b2, d3ch6d2
      automated match to d1xu9a_
      complexed with 311, nap; mutant
    3. 2090637Domain d3ch6d1: 3ch6 D:24-284 [173243]
      Other proteins in same PDB: d3ch6b2, d3ch6d2
      automated match to d1xu9a_
      complexed with 311, nap; mutant
    4. 2090638Domain d3ch6e_: 3ch6 E: [173244]
      Other proteins in same PDB: d3ch6b2, d3ch6d2
      automated match to d1xu9a_
      complexed with 311, nap; mutant
  10. Domain(s) for 3czr:
    1. 2090646Domain d3czra2: 3czr A:24-285 [157154]
      Other proteins in same PDB: d3czra3, d3czrb3
      automated match to d1xu9a_
      complexed with 3cz, cps, nap
    2. 2090647Domain d3czrb2: 3czr B:24-283 [157155]
      Other proteins in same PDB: d3czra3, d3czrb3
      automated match to d1xu9a_
      complexed with 3cz, cps, nap
  11. Domain(s) for 3d3e:
    1. 2090672Domain d3d3ea2: 3d3e A:24-284 [157280]
      Other proteins in same PDB: d3d3ea3, d3d3eb3, d3d3ec3, d3d3ed3
      automated match to d1xu9a_
      complexed with d3e, nap
    2. 2090673Domain d3d3eb2: 3d3e B:24-281 [157281]
      Other proteins in same PDB: d3d3ea3, d3d3eb3, d3d3ec3, d3d3ed3
      automated match to d1xu9a_
      complexed with d3e, nap
    3. 2090674Domain d3d3ec2: 3d3e C:24-281 [157282]
      Other proteins in same PDB: d3d3ea3, d3d3eb3, d3d3ec3, d3d3ed3
      automated match to d1xu9a_
      complexed with d3e, nap
    4. 2090675Domain d3d3ed2: 3d3e D:24-281 [157283]
      Other proteins in same PDB: d3d3ea3, d3d3eb3, d3d3ec3, d3d3ed3
      automated match to d1xu9a_
      complexed with d3e, nap
  12. Domain(s) for 3d4n:
    1. 2090660Domain d3d4na2: 3d4n A:24-282 [157296]
      Other proteins in same PDB: d3d4na3, d3d4nb3, d3d4nc3, d3d4nd3
      automated match to d1xu9a_
      complexed with d4n, nap
    2. 2090661Domain d3d4nb2: 3d4n B:24-284 [157297]
      Other proteins in same PDB: d3d4na3, d3d4nb3, d3d4nc3, d3d4nd3
      automated match to d1xu9a_
      complexed with d4n, nap
    3. 2090662Domain d3d4nc2: 3d4n C:24-281 [157298]
      Other proteins in same PDB: d3d4na3, d3d4nb3, d3d4nc3, d3d4nd3
      automated match to d1xu9a_
      complexed with d4n, nap
    4. 2090663Domain d3d4nd2: 3d4n D:24-281 [157299]
      Other proteins in same PDB: d3d4na3, d3d4nb3, d3d4nc3, d3d4nd3
      automated match to d1xu9a_
      complexed with d4n, nap
  13. Domain(s) for 3d5q:
    1. 2090668Domain d3d5qa2: 3d5q A:24-289 [157399]
      Other proteins in same PDB: d3d5qa3, d3d5qb3, d3d5qc3, d3d5qd3
      automated match to d1xu9a_
      complexed with nap, t30
    2. 2090669Domain d3d5qb2: 3d5q B:24-284 [157400]
      Other proteins in same PDB: d3d5qa3, d3d5qb3, d3d5qc3, d3d5qd3
      automated match to d1xu9a_
      complexed with nap, t30
    3. 2090670Domain d3d5qc2: 3d5q C:24-281 [157401]
      Other proteins in same PDB: d3d5qa3, d3d5qb3, d3d5qc3, d3d5qd3
      automated match to d1xu9a_
      complexed with nap, t30
    4. 2090671Domain d3d5qd2: 3d5q D:24-281 [157402]
      Other proteins in same PDB: d3d5qa3, d3d5qb3, d3d5qc3, d3d5qd3
      automated match to d1xu9a_
      complexed with nap, t30
  14. Domain(s) for 3ey4:
    1. 2090688Domain d3ey4a_: 3ey4 A: [245988]
      automated match to d3pdjb_
      complexed with 352, ndp
    2. 2090689Domain d3ey4b_: 3ey4 B: [245989]
      automated match to d3pdjb_
      complexed with 352, ndp
    3. 2090690Domain d3ey4c_: 3ey4 C: [245990]
      automated match to d3pdjb_
      complexed with 352, ndp
    4. 2090691Domain d3ey4d_: 3ey4 D: [245991]
      automated match to d3pdjb_
      complexed with 352, ndp
  15. Domain(s) for 3fco:
    1. 2090676Domain d3fcoa1: 3fco A:24-289 [175688]
      Other proteins in same PDB: d3fcoa2, d3fcob2
      automated match to d1xu9a_
      complexed with iig, nap
    2. 2090677Domain d3fcob1: 3fco B:24-289 [175689]
      Other proteins in same PDB: d3fcoa2, d3fcob2
      automated match to d1xu9a_
      complexed with iig, nap
  16. Domain(s) for 3frj:
    1. 2090633Domain d3frja1: 3frj A:24-284 [176002]
      Other proteins in same PDB: d3frja2, d3frjb2
      automated match to d1xu9a_
      complexed with a49, nap
    2. 2090634Domain d3frjb1: 3frj B:24-284 [176003]
      Other proteins in same PDB: d3frja2, d3frjb2
      automated match to d1xu9a_
      complexed with a49, nap
  17. Domain(s) for 3h6k:
    1. 2090625Domain d3h6ka_: 3h6k A: [177284]
      Other proteins in same PDB: d3h6kb2
      automated match to d1xu9a_
      complexed with 33t, nap
    2. 2090626Domain d3h6kb1: 3h6k B:24-282 [177285]
      Other proteins in same PDB: d3h6kb2
      automated match to d1xu9a_
      complexed with 33t, nap
    3. 2090627Domain d3h6kc_: 3h6k C: [177286]
      Other proteins in same PDB: d3h6kb2
      automated match to d1xu9a_
      complexed with 33t, nap
    4. 2090628Domain d3h6kd_: 3h6k D: [177287]
      Other proteins in same PDB: d3h6kb2
      automated match to d1xu9a_
      complexed with 33t, nap
  18. Domain(s) for 3hfg:
    1. 2090648Domain d3hfga_: 3hfg A: [177530]
      Other proteins in same PDB: d3hfgb2
      automated match to d1xu9a_
      complexed with 17r, nap
    2. 2090649Domain d3hfgb1: 3hfg B:24-282 [177531]
      Other proteins in same PDB: d3hfgb2
      automated match to d1xu9a_
      complexed with 17r, nap
    3. 2090650Domain d3hfgc_: 3hfg C: [177532]
      Other proteins in same PDB: d3hfgb2
      automated match to d1xu9a_
      complexed with 17r, nap
    4. 2090651Domain d3hfgd_: 3hfg D: [177533]
      Other proteins in same PDB: d3hfgb2
      automated match to d1xu9a_
      complexed with 17r, nap
  19. Domain(s) for 3oq1:
    1. 2090682Domain d3oq1a1: 3oq1 A:24-281 [214474]
      Other proteins in same PDB: d3oq1a2, d3oq1b2, d3oq1c2, d3oq1d2
      automated match to d1xu9a_
      complexed with 3oq, nap
    2. 2090683Domain d3oq1b1: 3oq1 B:24-287 [214475]
      Other proteins in same PDB: d3oq1a2, d3oq1b2, d3oq1c2, d3oq1d2
      automated match to d1xu9a_
      complexed with 3oq, nap
    3. 2090684Domain d3oq1c1: 3oq1 C:24-289 [214476]
      Other proteins in same PDB: d3oq1a2, d3oq1b2, d3oq1c2, d3oq1d2
      automated match to d1xu9a_
      complexed with 3oq, nap
    4. 2090685Domain d3oq1d1: 3oq1 D:24-281 [214477]
      Other proteins in same PDB: d3oq1a2, d3oq1b2, d3oq1c2, d3oq1d2
      automated match to d1xu9a_
      complexed with 3oq, nap
  20. Domain(s) for 3pdj:
    1. 2090639Domain d3pdja1: 3pdj A:24-291 [183673]
      Other proteins in same PDB: d3pdja2, d3pdjb2
      automated match to d1xu9b_
      complexed with 3pj, nap
    2. 2090640Domain d3pdjb1: 3pdj B:24-292 [183674]
      Other proteins in same PDB: d3pdja2, d3pdjb2
      automated match to d1xu9b_
      complexed with 3pj, nap
  21. Domain(s) for 3qqp:
    1. 2090642Domain d3qqpa1: 3qqp A:24-289 [215369]
      Other proteins in same PDB: d3qqpa2, d3qqpb2, d3qqpc2, d3qqpd2
      automated match to d1xu9b_
      complexed with ndp, s05
    2. 2090643Domain d3qqpb1: 3qqp B:24-285 [215370]
      Other proteins in same PDB: d3qqpa2, d3qqpb2, d3qqpc2, d3qqpd2
      automated match to d1xu9b_
      complexed with ndp, s05
    3. 2090644Domain d3qqpc1: 3qqp C:24-281 [215371]
      Other proteins in same PDB: d3qqpa2, d3qqpb2, d3qqpc2, d3qqpd2
      automated match to d1xu9b_
      complexed with ndp, s05
    4. 2090645Domain d3qqpd1: 3qqp D:24-277 [215372]
      Other proteins in same PDB: d3qqpa2, d3qqpb2, d3qqpc2, d3qqpd2
      automated match to d1xu9b_
      complexed with ndp, s05
  22. Domain(s) for 3tfq:
    1. 2090601Domain d3tfqa_: 3tfq A: [185814]
      Other proteins in same PDB: d3tfqb2, d3tfqd2
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant
    2. 2090602Domain d3tfqb1: 3tfq B:24-290 [185815]
      Other proteins in same PDB: d3tfqb2, d3tfqd2
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant
    3. 2090603Domain d3tfqd1: 3tfq D:24-284 [185816]
      Other proteins in same PDB: d3tfqb2, d3tfqd2
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant
    4. 2090604Domain d3tfqe_: 3tfq E: [185817]
      Other proteins in same PDB: d3tfqb2, d3tfqd2
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant
  23. Domain(s) for 4hfr:
    1. 2090686Domain d4hfra_: 4hfr A: [222558]
      automated match to d3pdjb_
      complexed with 14m, nap
    2. 2090687Domain d4hfrb_: 4hfr B: [222559]
      automated match to d3pdjb_
      complexed with 14m, nap
  24. Domain(s) for 4hx5:
    1. 2090617Domain d4hx5a_: 4hx5 A: [197024]
      Other proteins in same PDB: d4hx5b2, d4hx5c2, d4hx5d2
      automated match to d3pdjb_
      complexed with 19v, ndp
    2. 2090618Domain d4hx5b1: 4hx5 B:24-283 [197314]
      Other proteins in same PDB: d4hx5b2, d4hx5c2, d4hx5d2
      automated match to d3pdjb_
      complexed with 19v, ndp
    3. 2090619Domain d4hx5c1: 4hx5 C:24-284 [197313]
      Other proteins in same PDB: d4hx5b2, d4hx5c2, d4hx5d2
      automated match to d3pdjb_
      complexed with 19v, ndp
    4. 2090620Domain d4hx5d1: 4hx5 D:24-279 [202508]
      Other proteins in same PDB: d4hx5b2, d4hx5c2, d4hx5d2
      automated match to d1xu9b_
      complexed with 19v, ndp
  25. Domain(s) for 4iju:
    1. 2090652Domain d4ijua_: 4iju A: [256781]
      Other proteins in same PDB: d4ijub2, d4ijud2
      automated match to d3tfqb_
      complexed with 1eo, cl, nap; mutant
    2. 2090653Domain d4ijub1: 4iju B:11-291 [262723]
      Other proteins in same PDB: d4ijub2, d4ijud2
      automated match to d3tfqb_
      complexed with 1eo, cl, nap; mutant
    3. 2090654Domain d4ijud1: 4iju D:11-284 [258662]
      Other proteins in same PDB: d4ijub2, d4ijud2
      automated match to d3tfqb_
      complexed with 1eo, cl, nap; mutant
    4. 2090655Domain d4ijue_: 4iju E: [262724]
      Other proteins in same PDB: d4ijub2, d4ijud2
      automated match to d3tfqb_
      complexed with 1eo, cl, nap; mutant
  26. Domain(s) for 4ijv:
    1. 2090656Domain d4ijva_: 4ijv A: [266432]
      Other proteins in same PDB: d4ijvb2, d4ijvd2
      automated match to d3tfqb_
      complexed with 1en, nap; mutant
    2. 2090657Domain d4ijvb1: 4ijv B:11-290 [266433]
      Other proteins in same PDB: d4ijvb2, d4ijvd2
      automated match to d3tfqb_
      complexed with 1en, nap; mutant
    3. 2090658Domain d4ijvd1: 4ijv D:11-284 [266434]
      Other proteins in same PDB: d4ijvb2, d4ijvd2
      automated match to d3tfqb_
      complexed with 1en, nap; mutant
    4. 2090659Domain d4ijve_: 4ijv E: [266435]
      Other proteins in same PDB: d4ijvb2, d4ijvd2
      automated match to d3tfqb_
      complexed with 1en, nap; mutant
  27. Domain(s) for 4ijw:
    1. 2090664Domain d4ijwa_: 4ijw A: [266436]
      Other proteins in same PDB: d4ijwb2, d4ijwd2
      automated match to d3tfqb_
      complexed with 1eq, nap; mutant
    2. 2090665Domain d4ijwb1: 4ijw B:11-288 [266437]
      Other proteins in same PDB: d4ijwb2, d4ijwd2
      automated match to d3tfqb_
      complexed with 1eq, nap; mutant
    3. 2090666Domain d4ijwd1: 4ijw D:11-284 [266438]
      Other proteins in same PDB: d4ijwb2, d4ijwd2
      automated match to d3tfqb_
      complexed with 1eq, nap; mutant
    4. 2090667Domain d4ijwe_: 4ijw E: [266439]
      Other proteins in same PDB: d4ijwb2, d4ijwd2
      automated match to d3tfqb_
      complexed with 1eq, nap; mutant
  28. Domain(s) for 4k1l:
    1. 2090621Domain d4k1la1: 4k1l A:24-283 [238381]
      Other proteins in same PDB: d4k1la2, d4k1lb2, d4k1lc2, d4k1ld2
      automated match to d1xu9a_
      complexed with ndp, sff
    2. 2090622Domain d4k1lb1: 4k1l B:24-285 [238387]
      Other proteins in same PDB: d4k1la2, d4k1lb2, d4k1lc2, d4k1ld2
      automated match to d1xu9b_
      complexed with ndp, sff
    3. 2090623Domain d4k1lc1: 4k1l C:24-289 [238389]
      Other proteins in same PDB: d4k1la2, d4k1lb2, d4k1lc2, d4k1ld2
      automated match to d1xu9a_
      complexed with ndp, sff
    4. 2090624Domain d4k1ld1: 4k1l D:24-283 [238390]
      Other proteins in same PDB: d4k1la2, d4k1lb2, d4k1lc2, d4k1ld2
      automated match to d1xu9b_
      complexed with ndp, sff
  29. Domain(s) for 4p38:
    1. 2090700Domain d4p38a_: 4p38 A: [257395]
      automated match to d4bb6a_
      complexed with 21t, cl, ndp
    2. 2090701Domain d4p38b_: 4p38 B: [260937]
      automated match to d4bb6a_
      complexed with 21t, cl, ndp

More info for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1: