Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2841004Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2841005Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2841375Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
    has additional subdomain(s) that are not in the common domain
  6. 2841402Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
  7. 2841418Species Human (Homo sapiens) [TaxId:9606] [117424] (29 PDB entries)
    Uniprot P28845

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 1xu7:
    1. 2841427Domain d1xu7a1: 1xu7 A:24-283 [116048]
      Other proteins in same PDB: d1xu7a2, d1xu7b2, d1xu7c2, d1xu7d2
      complexed with cps, ndp
    2. 2841428Domain d1xu7b1: 1xu7 B:24-282 [116049]
      Other proteins in same PDB: d1xu7a2, d1xu7b2, d1xu7c2, d1xu7d2
      complexed with cps, ndp
    3. 2841429Domain d1xu7c1: 1xu7 C:24-282 [116050]
      Other proteins in same PDB: d1xu7a2, d1xu7b2, d1xu7c2, d1xu7d2
      complexed with cps, ndp
    4. 2841430Domain d1xu7d1: 1xu7 D:24-281 [116051]
      Other proteins in same PDB: d1xu7a2, d1xu7b2, d1xu7c2, d1xu7d2
      complexed with cps, ndp
  2. Domain(s) for 1xu9:
    1. 2841419Domain d1xu9a1: 1xu9 A:24-289 [116052]
      Other proteins in same PDB: d1xu9a2, d1xu9b2, d1xu9c2, d1xu9d2
      complexed with cps, mes, ndp
    2. 2841420Domain d1xu9b1: 1xu9 B:24-289 [116053]
      Other proteins in same PDB: d1xu9a2, d1xu9b2, d1xu9c2, d1xu9d2
      complexed with cps, mes, ndp
    3. 2841421Domain d1xu9c1: 1xu9 C:24-281 [116054]
      Other proteins in same PDB: d1xu9a2, d1xu9b2, d1xu9c2, d1xu9d2
      complexed with cps, mes, ndp
    4. 2841422Domain d1xu9d1: 1xu9 D:24-281 [116055]
      Other proteins in same PDB: d1xu9a2, d1xu9b2, d1xu9c2, d1xu9d2
      complexed with cps, mes, ndp
  3. Domain(s) for 2bel:
    1. 2841465Domain d2bela_: 2bel A: [116694]
      Other proteins in same PDB: d2belc2, d2beld2
      complexed with cbo, cl, nap
    2. 2841466Domain d2belb_: 2bel B: [116695]
      Other proteins in same PDB: d2belc2, d2beld2
      complexed with cbo, cl, nap
    3. 2841467Domain d2belc1: 2bel C:26-271 [116696]
      Other proteins in same PDB: d2belc2, d2beld2
      complexed with cbo, cl, nap
    4. 2841468Domain d2beld1: 2bel D:26-277 [116697]
      Other proteins in same PDB: d2belc2, d2beld2
      complexed with cbo, cl, nap
  4. Domain(s) for 2ilt:
  5. Domain(s) for 2irw:
    1. 2841516Domain d2irwa_: 2irw A: [137593]
      automated match to d2irwa1
      complexed with nap, nn4
    2. 2841517Domain d2irwb_: 2irw B: [137594]
      automated match to d2irwb1
      complexed with nap, nn4
    3. 2841518Domain d2irwc_: 2irw C: [137595]
      automated match to d2irwd1
      complexed with nap, nn4
    4. 2841519Domain d2irwd_: 2irw D: [137596]
      automated match to d2irwd1
      complexed with nap, nn4
    5. 2841520Domain d2irwe_: 2irw E: [137597]
      automated match to d2irwd1
      complexed with nap, nn4
    6. 2841521Domain d2irwf_: 2irw F: [137598]
      automated match to d2irwf1
      complexed with nap, nn4
    7. 2841522Domain d2irwg_: 2irw G: [137599]
      automated match to d2irwg1
      complexed with nap, nn4
    8. 2841523Domain d2irwh_: 2irw H: [137600]
      automated match to d2irwg1
      complexed with nap, nn4
  6. Domain(s) for 2rbe:
    1. 2841447Domain d2rbea_: 2rbe A: [151846]
      automated match to d1xu9a_
      complexed with ndp, zmg
    2. 2841448Domain d2rbeb_: 2rbe B: [151847]
      automated match to d1xu9a_
      complexed with ndp, zmg
    3. 2841449Domain d2rbec_: 2rbe C: [151848]
      automated match to d1xu9a_
      complexed with ndp, zmg
    4. 2841450Domain d2rbed_: 2rbe D: [151849]
      automated match to d1xu9a_
      complexed with ndp, zmg
  7. Domain(s) for 3byz:
    1. 2841487Domain d3byza_: 3byz A: [155734]
      automated match to d1xu9a_
      complexed with h11, ndp
    2. 2841488Domain d3byzb_: 3byz B: [155735]
      automated match to d1xu9a_
      complexed with h11, ndp
    3. 2841489Domain d3byzc_: 3byz C: [155736]
      automated match to d1xu9a_
      complexed with h11, ndp
    4. 2841490Domain d3byzd_: 3byz D: [155737]
      automated match to d1xu9a_
      complexed with h11, ndp
  8. Domain(s) for 3bzu:
    1. 2841439Domain d3bzua_: 3bzu A: [155788]
      Other proteins in same PDB: d3bzub3
      automated match to d1xu9a_
      complexed with a21, nap
    2. 2841440Domain d3bzub2: 3bzu B:24-283 [155789]
      Other proteins in same PDB: d3bzub3
      automated match to d1xu9a_
      complexed with a21, nap
    3. 2841441Domain d3bzuc_: 3bzu C: [155790]
      Other proteins in same PDB: d3bzub3
      automated match to d1xu9a_
      complexed with a21, nap
    4. 2841442Domain d3bzud_: 3bzu D: [155791]
      Other proteins in same PDB: d3bzub3
      automated match to d1xu9a_
      complexed with a21, nap
  9. Domain(s) for 3ch6:
    1. 2841500Domain d3ch6a_: 3ch6 A: [173241]
      Other proteins in same PDB: d3ch6b2, d3ch6d2
      automated match to d1xu9a_
      complexed with 311, nap; mutant
    2. 2841501Domain d3ch6b1: 3ch6 B:24-288 [173242]
      Other proteins in same PDB: d3ch6b2, d3ch6d2
      automated match to d1xu9a_
      complexed with 311, nap; mutant
    3. 2841502Domain d3ch6d1: 3ch6 D:24-284 [173243]
      Other proteins in same PDB: d3ch6b2, d3ch6d2
      automated match to d1xu9a_
      complexed with 311, nap; mutant
    4. 2841503Domain d3ch6e_: 3ch6 E: [173244]
      Other proteins in same PDB: d3ch6b2, d3ch6d2
      automated match to d1xu9a_
      complexed with 311, nap; mutant
  10. Domain(s) for 3czr:
    1. 2841451Domain d3czra2: 3czr A:24-285 [157154]
      Other proteins in same PDB: d3czra3, d3czrb3
      automated match to d1xu9a_
      complexed with 3cz, cps, nap
    2. 2841452Domain d3czrb2: 3czr B:24-283 [157155]
      Other proteins in same PDB: d3czra3, d3czrb3
      automated match to d1xu9a_
      complexed with 3cz, cps, nap
  11. Domain(s) for 3d3e:
    1. 2841477Domain d3d3ea2: 3d3e A:24-284 [157280]
      Other proteins in same PDB: d3d3ea3, d3d3eb3, d3d3ec3, d3d3ed3
      automated match to d1xu9a_
      complexed with d3e, nap
    2. 2841478Domain d3d3eb2: 3d3e B:24-281 [157281]
      Other proteins in same PDB: d3d3ea3, d3d3eb3, d3d3ec3, d3d3ed3
      automated match to d1xu9a_
      complexed with d3e, nap
    3. 2841479Domain d3d3ec2: 3d3e C:24-281 [157282]
      Other proteins in same PDB: d3d3ea3, d3d3eb3, d3d3ec3, d3d3ed3
      automated match to d1xu9a_
      complexed with d3e, nap
    4. 2841480Domain d3d3ed2: 3d3e D:24-281 [157283]
      Other proteins in same PDB: d3d3ea3, d3d3eb3, d3d3ec3, d3d3ed3
      automated match to d1xu9a_
      complexed with d3e, nap
  12. Domain(s) for 3d4n:
    1. 2841461Domain d3d4na2: 3d4n A:24-282 [157296]
      Other proteins in same PDB: d3d4na3, d3d4nb3, d3d4nc3, d3d4nd3
      automated match to d1xu9a_
      complexed with d4n, nap
    2. 2841462Domain d3d4nb2: 3d4n B:24-284 [157297]
      Other proteins in same PDB: d3d4na3, d3d4nb3, d3d4nc3, d3d4nd3
      automated match to d1xu9a_
      complexed with d4n, nap
    3. 2841463Domain d3d4nc2: 3d4n C:24-281 [157298]
      Other proteins in same PDB: d3d4na3, d3d4nb3, d3d4nc3, d3d4nd3
      automated match to d1xu9a_
      complexed with d4n, nap
    4. 2841464Domain d3d4nd2: 3d4n D:24-281 [157299]
      Other proteins in same PDB: d3d4na3, d3d4nb3, d3d4nc3, d3d4nd3
      automated match to d1xu9a_
      complexed with d4n, nap
  13. Domain(s) for 3d5q:
    1. 2841473Domain d3d5qa2: 3d5q A:24-289 [157399]
      Other proteins in same PDB: d3d5qa3, d3d5qb3, d3d5qc3, d3d5qd3
      automated match to d1xu9a_
      complexed with nap, t30
    2. 2841474Domain d3d5qb2: 3d5q B:24-284 [157400]
      Other proteins in same PDB: d3d5qa3, d3d5qb3, d3d5qc3, d3d5qd3
      automated match to d1xu9a_
      complexed with nap, t30
    3. 2841475Domain d3d5qc2: 3d5q C:24-281 [157401]
      Other proteins in same PDB: d3d5qa3, d3d5qb3, d3d5qc3, d3d5qd3
      automated match to d1xu9a_
      complexed with nap, t30
    4. 2841476Domain d3d5qd2: 3d5q D:24-281 [157402]
      Other proteins in same PDB: d3d5qa3, d3d5qb3, d3d5qc3, d3d5qd3
      automated match to d1xu9a_
      complexed with nap, t30
  14. Domain(s) for 3ey4:
    1. 2841512Domain d3ey4a_: 3ey4 A: [245988]
      automated match to d3pdjb_
      complexed with 352, ndp
    2. 2841513Domain d3ey4b_: 3ey4 B: [245989]
      automated match to d3pdjb_
      complexed with 352, ndp
    3. 2841514Domain d3ey4c_: 3ey4 C: [245990]
      automated match to d3pdjb_
      complexed with 352, ndp
    4. 2841515Domain d3ey4d_: 3ey4 D: [245991]
      automated match to d3pdjb_
      complexed with 352, ndp
  15. Domain(s) for 3fco:
    1. 2841481Domain d3fcoa1: 3fco A:24-289 [175688]
      Other proteins in same PDB: d3fcoa2, d3fcob2
      automated match to d1xu9a_
      complexed with iig, nap
    2. 2841482Domain d3fcob1: 3fco B:24-289 [175689]
      Other proteins in same PDB: d3fcoa2, d3fcob2
      automated match to d1xu9a_
      complexed with iig, nap
  16. Domain(s) for 3frj:
    1. 2841443Domain d3frja1: 3frj A:24-284 [176002]
      Other proteins in same PDB: d3frja2, d3frjb2
      automated match to d1xu9a_
      complexed with a49, nap
    2. 2841444Domain d3frjb1: 3frj B:24-284 [176003]
      Other proteins in same PDB: d3frja2, d3frjb2
      automated match to d1xu9a_
      complexed with a49, nap
  17. Domain(s) for 3h6k:
    1. 2841483Domain d3h6ka_: 3h6k A: [177284]
      Other proteins in same PDB: d3h6kb2
      automated match to d1xu9a_
      complexed with 33t, nap
    2. 2841484Domain d3h6kb1: 3h6k B:24-282 [177285]
      Other proteins in same PDB: d3h6kb2
      automated match to d1xu9a_
      complexed with 33t, nap
    3. 2841485Domain d3h6kc_: 3h6k C: [177286]
      Other proteins in same PDB: d3h6kb2
      automated match to d1xu9a_
      complexed with 33t, nap
    4. 2841486Domain d3h6kd_: 3h6k D: [177287]
      Other proteins in same PDB: d3h6kb2
      automated match to d1xu9a_
      complexed with 33t, nap
  18. Domain(s) for 3hfg:
    1. 2841496Domain d3hfga_: 3hfg A: [177530]
      Other proteins in same PDB: d3hfgb2
      automated match to d1xu9a_
      complexed with 17r, nap
    2. 2841497Domain d3hfgb1: 3hfg B:24-282 [177531]
      Other proteins in same PDB: d3hfgb2
      automated match to d1xu9a_
      complexed with 17r, nap
    3. 2841498Domain d3hfgc_: 3hfg C: [177532]
      Other proteins in same PDB: d3hfgb2
      automated match to d1xu9a_
      complexed with 17r, nap
    4. 2841499Domain d3hfgd_: 3hfg D: [177533]
      Other proteins in same PDB: d3hfgb2
      automated match to d1xu9a_
      complexed with 17r, nap
  19. Domain(s) for 3oq1:
    1. 2841491Domain d3oq1a1: 3oq1 A:24-281 [214474]
      Other proteins in same PDB: d3oq1a2, d3oq1b2, d3oq1c2, d3oq1d2
      automated match to d1xu9a_
      complexed with 3oq, nap
    2. 2841492Domain d3oq1b1: 3oq1 B:24-287 [214475]
      Other proteins in same PDB: d3oq1a2, d3oq1b2, d3oq1c2, d3oq1d2
      automated match to d1xu9a_
      complexed with 3oq, nap
    3. 2841493Domain d3oq1c1: 3oq1 C:24-289 [214476]
      Other proteins in same PDB: d3oq1a2, d3oq1b2, d3oq1c2, d3oq1d2
      automated match to d1xu9a_
      complexed with 3oq, nap
    4. 2841494Domain d3oq1d1: 3oq1 D:24-281 [214477]
      Other proteins in same PDB: d3oq1a2, d3oq1b2, d3oq1c2, d3oq1d2
      automated match to d1xu9a_
      complexed with 3oq, nap
  20. Domain(s) for 3pdj:
    1. 2841445Domain d3pdja1: 3pdj A:24-291 [183673]
      Other proteins in same PDB: d3pdja2, d3pdjb2
      automated match to d1xu9b_
      complexed with 3pj, nap
    2. 2841446Domain d3pdjb1: 3pdj B:24-292 [183674]
      Other proteins in same PDB: d3pdja2, d3pdjb2
      automated match to d1xu9b_
      complexed with 3pj, nap
  21. Domain(s) for 3qqp:
    1. 2841506Domain d3qqpa1: 3qqp A:24-289 [215369]
      Other proteins in same PDB: d3qqpa2, d3qqpb2, d3qqpc2, d3qqpd2
      automated match to d1xu9b_
      complexed with ndp, s05
    2. 2841507Domain d3qqpb1: 3qqp B:24-285 [215370]
      Other proteins in same PDB: d3qqpa2, d3qqpb2, d3qqpc2, d3qqpd2
      automated match to d1xu9b_
      complexed with ndp, s05
    3. 2841508Domain d3qqpc1: 3qqp C:24-281 [215371]
      Other proteins in same PDB: d3qqpa2, d3qqpb2, d3qqpc2, d3qqpd2
      automated match to d1xu9b_
      complexed with ndp, s05
    4. 2841509Domain d3qqpd1: 3qqp D:24-277 [215372]
      Other proteins in same PDB: d3qqpa2, d3qqpb2, d3qqpc2, d3qqpd2
      automated match to d1xu9b_
      complexed with ndp, s05
  22. Domain(s) for 3tfq:
    1. 2841423Domain d3tfqa_: 3tfq A: [185814]
      Other proteins in same PDB: d3tfqb2, d3tfqd2
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant
    2. 2841424Domain d3tfqb1: 3tfq B:24-290 [185815]
      Other proteins in same PDB: d3tfqb2, d3tfqd2
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant
    3. 2841425Domain d3tfqd1: 3tfq D:24-284 [185816]
      Other proteins in same PDB: d3tfqb2, d3tfqd2
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant
    4. 2841426Domain d3tfqe_: 3tfq E: [185817]
      Other proteins in same PDB: d3tfqb2, d3tfqd2
      automated match to d1xu9a_
      complexed with 07m, gol, nap; mutant
  23. Domain(s) for 4hfr:
    1. 2841504Domain d4hfra_: 4hfr A: [222558]
      automated match to d3pdjb_
      complexed with 14m, nap
    2. 2841505Domain d4hfrb_: 4hfr B: [222559]
      automated match to d3pdjb_
      complexed with 14m, nap
  24. Domain(s) for 4hx5:
    1. 2841431Domain d4hx5a_: 4hx5 A: [197024]
      Other proteins in same PDB: d4hx5b2, d4hx5c2, d4hx5d2
      automated match to d3pdjb_
      complexed with 19v, ndp
    2. 2841432Domain d4hx5b1: 4hx5 B:24-283 [197314]
      Other proteins in same PDB: d4hx5b2, d4hx5c2, d4hx5d2
      automated match to d3pdjb_
      complexed with 19v, ndp
    3. 2841433Domain d4hx5c1: 4hx5 C:24-284 [197313]
      Other proteins in same PDB: d4hx5b2, d4hx5c2, d4hx5d2
      automated match to d3pdjb_
      complexed with 19v, ndp
    4. 2841434Domain d4hx5d1: 4hx5 D:24-279 [202508]
      Other proteins in same PDB: d4hx5b2, d4hx5c2, d4hx5d2
      automated match to d1xu9b_
      complexed with 19v, ndp
  25. Domain(s) for 4iju:
    1. 2841453Domain d4ijua_: 4iju A: [256781]
      Other proteins in same PDB: d4ijub2, d4ijud2
      automated match to d3tfqb_
      complexed with 1eo, cl, nap; mutant
    2. 2841454Domain d4ijub1: 4iju B:11-291 [262723]
      Other proteins in same PDB: d4ijub2, d4ijud2
      automated match to d3tfqb_
      complexed with 1eo, cl, nap; mutant
    3. 2841455Domain d4ijud1: 4iju D:11-284 [258662]
      Other proteins in same PDB: d4ijub2, d4ijud2
      automated match to d3tfqb_
      complexed with 1eo, cl, nap; mutant
    4. 2841456Domain d4ijue_: 4iju E: [262724]
      Other proteins in same PDB: d4ijub2, d4ijud2
      automated match to d3tfqb_
      complexed with 1eo, cl, nap; mutant
  26. Domain(s) for 4ijv:
    1. 2841457Domain d4ijva_: 4ijv A: [266432]
      Other proteins in same PDB: d4ijvb2, d4ijvd2
      automated match to d3tfqb_
      complexed with 1en, nap; mutant
    2. 2841458Domain d4ijvb1: 4ijv B:11-290 [266433]
      Other proteins in same PDB: d4ijvb2, d4ijvd2
      automated match to d3tfqb_
      complexed with 1en, nap; mutant
    3. 2841459Domain d4ijvd1: 4ijv D:11-284 [266434]
      Other proteins in same PDB: d4ijvb2, d4ijvd2
      automated match to d3tfqb_
      complexed with 1en, nap; mutant
    4. 2841460Domain d4ijve_: 4ijv E: [266435]
      Other proteins in same PDB: d4ijvb2, d4ijvd2
      automated match to d3tfqb_
      complexed with 1en, nap; mutant
  27. Domain(s) for 4ijw:
    1. 2841469Domain d4ijwa_: 4ijw A: [266436]
      Other proteins in same PDB: d4ijwb2, d4ijwd2
      automated match to d3tfqb_
      complexed with 1eq, nap; mutant
    2. 2841470Domain d4ijwb1: 4ijw B:11-288 [266437]
      Other proteins in same PDB: d4ijwb2, d4ijwd2
      automated match to d3tfqb_
      complexed with 1eq, nap; mutant
    3. 2841471Domain d4ijwd1: 4ijw D:11-284 [266438]
      Other proteins in same PDB: d4ijwb2, d4ijwd2
      automated match to d3tfqb_
      complexed with 1eq, nap; mutant
    4. 2841472Domain d4ijwe_: 4ijw E: [266439]
      Other proteins in same PDB: d4ijwb2, d4ijwd2
      automated match to d3tfqb_
      complexed with 1eq, nap; mutant
  28. Domain(s) for 4k1l:
    1. 2841435Domain d4k1la1: 4k1l A:24-283 [238381]
      Other proteins in same PDB: d4k1la2, d4k1lb2, d4k1lc2, d4k1ld2
      automated match to d1xu9a_
      complexed with ndp, sff
    2. 2841436Domain d4k1lb1: 4k1l B:24-285 [238387]
      Other proteins in same PDB: d4k1la2, d4k1lb2, d4k1lc2, d4k1ld2
      automated match to d1xu9b_
      complexed with ndp, sff
    3. 2841437Domain d4k1lc1: 4k1l C:24-289 [238389]
      Other proteins in same PDB: d4k1la2, d4k1lb2, d4k1lc2, d4k1ld2
      automated match to d1xu9a_
      complexed with ndp, sff
    4. 2841438Domain d4k1ld1: 4k1l D:24-283 [238390]
      Other proteins in same PDB: d4k1la2, d4k1lb2, d4k1lc2, d4k1ld2
      automated match to d1xu9b_
      complexed with ndp, sff
  29. Domain(s) for 4p38:
    1. 2841510Domain d4p38a_: 4p38 A: [257395]
      automated match to d4bb6a_
      complexed with 21t, cl, ndp
    2. 2841511Domain d4p38b_: 4p38 B: [260937]
      automated match to d4bb6a_
      complexed with 21t, cl, ndp

More info for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.2.1.2 11-beta-hydroxysteroid dehydrogenase 1: