Lineage for Protein: 11-beta-hydroxysteroid dehydrogenase 1

  1. Root: SCOPe 2.01
  2. 968085Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 975118Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 975119Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 975436Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 975463Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)

Species:

  1. 975464Guinea pig (Cavia porcellus) [TaxId:10141] [117425] (4 PDB entries)
    Uniprot Q6QLL4 23-296
    1. Domains for 1xse:
      1. 975473Domain d1xsea_: 1xse A: [115925]
        complexed with ndp
      2. 975474Domain d1xseb_: 1xse B: [115926]
        complexed with ndp
    2. Domains for 3dwf:
      1. 975469Domain d3dwfa1: 3dwf A:25-293 [174301]
        automated match to d1xsea_
        complexed with gol, nap, so4; mutant
      2. 975470Domain d3dwfb_: 3dwf B: [174302]
        automated match to d1xsea_
        complexed with gol, nap, so4; mutant
      3. 975471Domain d3dwfc1: 3dwf C:24-295 [174303]
        automated match to d1xsea_
        complexed with gol, nap, so4; mutant
      4. 975472Domain d3dwfd_: 3dwf D: [174304]
        automated match to d1xsea_
        complexed with gol, nap, so4; mutant
    3. Domains for 3g49:
      1. 975475Domain d3g49a_: 3g49 A: [176338]
        automated match to d1xsea_
        complexed with 3g4, nap
      2. 975476Domain d3g49b_: 3g49 B: [176339]
        automated match to d1xsea_
        complexed with 3g4, nap
      3. 975477Domain d3g49c_: 3g49 C: [176340]
        automated match to d1xsea_
        complexed with 3g4, nap
      4. 975478Domain d3g49d_: 3g49 D: [176341]
        automated match to d1xsea_
        complexed with 3g4, nap
    4. Domains for 3lz6:
      1. 975465Domain d3lz6a_: 3lz6 A: [180653]
        automated match to d1xsea_
        complexed with a0d, nap
      2. 975466Domain d3lz6b_: 3lz6 B: [180654]
        automated match to d1xsea_
        complexed with a0d, nap
      3. 975467Domain d3lz6c_: 3lz6 C: [180655]
        automated match to d1xsea_
        complexed with a0d, nap
      4. 975468Domain d3lz6d_: 3lz6 D: [180656]
        automated match to d1xsea_
        complexed with a0d, nap
  2. 975479Human (Homo sapiens) [TaxId:9606] [117424] (19 PDB entries)
    Uniprot P28845
    1. Domains for 1xu7:
      1. 975488Domain d1xu7a_: 1xu7 A: [116048]
        complexed with cps, ndp
      2. 975489Domain d1xu7b_: 1xu7 B: [116049]
        complexed with cps, ndp
      3. 975490Domain d1xu7c_: 1xu7 C: [116050]
        complexed with cps, ndp
      4. 975491Domain d1xu7d_: 1xu7 D: [116051]
        complexed with cps, ndp
    2. Domains for 1xu9:
      1. 975480Domain d1xu9a_: 1xu9 A: [116052]
        complexed with cps, mes, ndp
      2. 975481Domain d1xu9b_: 1xu9 B: [116053]
        complexed with cps, mes, ndp
      3. 975482Domain d1xu9c_: 1xu9 C: [116054]
        complexed with cps, mes, ndp
      4. 975483Domain d1xu9d_: 1xu9 D: [116055]
        complexed with cps, mes, ndp
    3. Domains for 2bel:
      1. 975496Domain d2bela_: 2bel A: [116694]
        complexed with cbo, cl, nap
      2. 975497Domain d2belb_: 2bel B: [116695]
        complexed with cbo, cl, nap
      3. 975498Domain d2belc_: 2bel C: [116696]
        complexed with cbo, cl, nap
      4. 975499Domain d2beld_: 2bel D: [116697]
        complexed with cbo, cl, nap
    4. Domain for 2ilt:
    5. Domains for 2irw:
      1. 975541Domain d2irwa1: 2irw A:26-289 [137593]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      2. 975542Domain d2irwb1: 2irw B:26-289 [137594]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      3. 975543Domain d2irwc1: 2irw C:26-282 [137595]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      4. 975544Domain d2irwd1: 2irw D:26-289 [137596]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      5. 975545Domain d2irwe1: 2irw E:26-282 [137597]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      6. 975546Domain d2irwf1: 2irw F:26-289 [137598]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      7. 975547Domain d2irwg1: 2irw G:26-289 [137599]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      8. 975548Domain d2irwh1: 2irw H:26-289 [137600]
        automatically matched to d1xu9b_
        complexed with nap, nn4
    6. Domains for 2rbe:
      1. 975492Domain d2rbea_: 2rbe A: [151846]
        automated match to d1xu9a_
        complexed with ndp, zmg
      2. 975493Domain d2rbeb_: 2rbe B: [151847]
        automated match to d1xu9a_
        complexed with ndp, zmg
      3. 975494Domain d2rbec_: 2rbe C: [151848]
        automated match to d1xu9a_
        complexed with ndp, zmg
      4. 975495Domain d2rbed_: 2rbe D: [151849]
        automated match to d1xu9a_
        complexed with ndp, zmg
    7. Domains for 3byz:
      1. 975537Domain d3byza_: 3byz A: [155734]
        automated match to d1xu9a_
        complexed with h11, ndp
      2. 975538Domain d3byzb_: 3byz B: [155735]
        automated match to d1xu9a_
        complexed with h11, ndp
      3. 975539Domain d3byzc_: 3byz C: [155736]
        automated match to d1xu9a_
        complexed with h11, ndp
      4. 975540Domain d3byzd_: 3byz D: [155737]
        automated match to d1xu9a_
        complexed with h11, ndp
    8. Domains for 3bzu:
      1. 975504Domain d3bzua_: 3bzu A: [155788]
        automated match to d1xu9a_
        complexed with a21, nap
      2. 975505Domain d3bzub_: 3bzu B: [155789]
        automated match to d1xu9a_
        complexed with a21, nap
      3. 975506Domain d3bzuc_: 3bzu C: [155790]
        automated match to d1xu9a_
        complexed with a21, nap
      4. 975507Domain d3bzud_: 3bzu D: [155791]
        automated match to d1xu9a_
        complexed with a21, nap
    9. Domains for 3ch6:
      1. 975510Domain d3ch6a_: 3ch6 A: [173241]
        automated match to d1xu9a_
        complexed with 311, nap; mutant
      2. 975511Domain d3ch6b_: 3ch6 B: [173242]
        automated match to d1xu9a_
        complexed with 311, nap; mutant
      3. 975512Domain d3ch6d_: 3ch6 D: [173243]
        automated match to d1xu9a_
        complexed with 311, nap; mutant
      4. 975513Domain d3ch6e_: 3ch6 E: [173244]
        automated match to d1xu9a_
        complexed with 311, nap; mutant
    10. Domains for 3czr:
      1. 975517Domain d3czra_: 3czr A: [157154]
        automated match to d1xu9a_
        complexed with 3cz, cps, nap
      2. 975518Domain d3czrb_: 3czr B: [157155]
        automated match to d1xu9a_
        complexed with 3cz, cps, nap
    11. Domains for 3d3e:
      1. 975531Domain d3d3ea_: 3d3e A: [157280]
        automated match to d1xu9a_
        complexed with d3e, nap
      2. 975532Domain d3d3eb_: 3d3e B: [157281]
        automated match to d1xu9a_
        complexed with d3e, nap
      3. 975533Domain d3d3ec_: 3d3e C: [157282]
        automated match to d1xu9a_
        complexed with d3e, nap
      4. 975534Domain d3d3ed_: 3d3e D: [157283]
        automated match to d1xu9a_
        complexed with d3e, nap
    12. Domains for 3d4n:
      1. 975523Domain d3d4na_: 3d4n A: [157296]
        automated match to d1xu9a_
        complexed with d4n, nap
      2. 975524Domain d3d4nb_: 3d4n B: [157297]
        automated match to d1xu9a_
        complexed with d4n, nap
      3. 975525Domain d3d4nc_: 3d4n C: [157298]
        automated match to d1xu9a_
        complexed with d4n, nap
      4. 975526Domain d3d4nd_: 3d4n D: [157299]
        automated match to d1xu9a_
        complexed with d4n, nap
    13. Domains for 3d5q:
      1. 975527Domain d3d5qa_: 3d5q A: [157399]
        automated match to d1xu9a_
        complexed with nap, t30
      2. 975528Domain d3d5qb_: 3d5q B: [157400]
        automated match to d1xu9a_
        complexed with nap, t30
      3. 975529Domain d3d5qc_: 3d5q C: [157401]
        automated match to d1xu9a_
        complexed with nap, t30
      4. 975530Domain d3d5qd_: 3d5q D: [157402]
        automated match to d1xu9a_
        complexed with nap, t30
    14. Domains for 3fco:
      1. 975535Domain d3fcoa_: 3fco A: [175688]
        automated match to d1xu9a_
        complexed with iig, nap
      2. 975536Domain d3fcob_: 3fco B: [175689]
        automated match to d1xu9a_
        complexed with iig, nap
    15. Domains for 3frj:
      1. 975508Domain d3frja_: 3frj A: [176002]
        automated match to d1xu9a_
        complexed with a49, nap
      2. 975509Domain d3frjb_: 3frj B: [176003]
        automated match to d1xu9a_
        complexed with a49, nap
    16. Domains for 3h6k:
      1. 975500Domain d3h6ka_: 3h6k A: [177284]
        automated match to d1xu9a_
        complexed with 33t, nap
      2. 975501Domain d3h6kb_: 3h6k B: [177285]
        automated match to d1xu9a_
        complexed with 33t, nap
      3. 975502Domain d3h6kc_: 3h6k C: [177286]
        automated match to d1xu9a_
        complexed with 33t, nap
      4. 975503Domain d3h6kd_: 3h6k D: [177287]
        automated match to d1xu9a_
        complexed with 33t, nap
    17. Domains for 3hfg:
      1. 975519Domain d3hfga_: 3hfg A: [177530]
        automated match to d1xu9a_
        complexed with 17r, nap
      2. 975520Domain d3hfgb_: 3hfg B: [177531]
        automated match to d1xu9a_
        complexed with 17r, nap
      3. 975521Domain d3hfgc_: 3hfg C: [177532]
        automated match to d1xu9a_
        complexed with 17r, nap
      4. 975522Domain d3hfgd_: 3hfg D: [177533]
        automated match to d1xu9a_
        complexed with 17r, nap
    18. Domains for 3pdj:
      1. 975514Domain d3pdja_: 3pdj A: [183673]
        automated match to d1xu9b_
        complexed with 3pj, nap
      2. 975515Domain d3pdjb_: 3pdj B: [183674]
        automated match to d1xu9b_
        complexed with 3pj, nap
    19. Domains for 3tfq:
      1. 975484Domain d3tfqa_: 3tfq A: [185814]
        automated match to d1xu9a_
        complexed with 07m, gol, nap; mutant
      2. 975485Domain d3tfqb_: 3tfq B: [185815]
        automated match to d1xu9a_
        complexed with 07m, gol, nap; mutant
      3. 975486Domain d3tfqd_: 3tfq D: [185816]
        automated match to d1xu9a_
        complexed with 07m, gol, nap; mutant
      4. 975487Domain d3tfqe_: 3tfq E: [185817]
        automated match to d1xu9a_
        complexed with 07m, gol, nap; mutant
  3. 975549Mouse (Mus musculus) [TaxId:10090] [141879] (3 PDB entries)
    Uniprot P50172 24-298
    1. Domains for 1y5m:
      1. 975550Domain d1y5ma1: 1y5m A:25-289 [122645]
        complexed with ndp, oct, so4
      2. 975551Domain d1y5mb_: 1y5m B: [122646]
        automated match to d1xu9a_
        complexed with ndp, oct, so4
    2. Domains for 1y5r:
      1. 975560Domain d1y5ra1: 1y5r A:25-289 [122651]
        automatically matched to 1Y5M A:25-289
        complexed with c0r, ndp
      2. 975561Domain d1y5rb1: 1y5r B:25-289 [122652]
        automatically matched to 1Y5M A:25-289
        complexed with c0r, ndp
    3. Domains for 3gmd:
      1. 975552Domain d3gmda_: 3gmd A: [176741]
        automated match to d1y5ma1
        complexed with 2m3, ndp, so4
      2. 975553Domain d3gmdb_: 3gmd B: [176742]
        automated match to d1y5ma1
        complexed with 2m3, ndp, so4
      3. 975554Domain d3gmdc_: 3gmd C: [176743]
        automated match to d1y5ma1
        complexed with 2m3, ndp, so4
      4. 975555Domain d3gmdd_: 3gmd D: [176744]
        automated match to d1y5ma1
        complexed with 2m3, ndp, so4
      5. 975556Domain d3gmde_: 3gmd E: [176745]
        automated match to d1y5ma1
        complexed with 2m3, ndp, so4
      6. 975557Domain d3gmdf_: 3gmd F: [176746]
        automated match to d1y5ma1
        complexed with 2m3, ndp, so4
      7. 975558Domain d3gmdg_: 3gmd G: [176747]
        automated match to d1y5ma1
        complexed with 2m3, ndp, so4
      8. 975559Domain d3gmdh_: 3gmd H: [176748]
        automated match to d1y5ma1
        complexed with 2m3, ndp, so4

More info for Protein 11-beta-hydroxysteroid dehydrogenase 1 from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein 11-beta-hydroxysteroid dehydrogenase 1 from c.2.1.2: Tyrosine-dependent oxidoreductases: