Class c: Alpha and beta proteins (a/b) [51349] (147 folds) |
Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily) core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456 The nucleotide-binding modes of this and the next two folds/superfamilies are similar |
Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families) |
Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins) also known as short-chain dehydrogenases and SDR family parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7 |
Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species) |
Guinea pig (Cavia porcellus) [TaxId:10141] [117425] (1 PDB entry) Uniprot Q6QLL4 23-296 |
Domain d1xsea_: 1xse A: [115925] |
Domain d1xseb_: 1xse B: [115926] complexed with ndp |
Human (Homo sapiens) [TaxId:9606] [117424] (11 PDB entries) Uniprot P28845 |
Domain d1xu7a_: 1xu7 A: [116048] |
Domain d1xu7b_: 1xu7 B: [116049] |
Domain d1xu7c_: 1xu7 C: [116050] |
Domain d1xu7d_: 1xu7 D: [116051] complexed with cps, ndp; mutant |
Domain d1xu9a_: 1xu9 A: [116052] |
Domain d1xu9b_: 1xu9 B: [116053] |
Domain d1xu9c_: 1xu9 C: [116054] |
Domain d1xu9d_: 1xu9 D: [116055] complexed with cps, mes, ndp; mutant |
Domain d2bela_: 2bel A: [116694] |
Domain d2belb_: 2bel B: [116695] |
Domain d2belc_: 2bel C: [116696] |
Domain d2beld_: 2bel D: [116697] complexed with cbo, cl, nap |
Domain d2irwa1: 2irw A:26-289 [137593] automatically matched to d1xu9b_ complexed with nap, nn4 |
Domain d2irwb1: 2irw B:26-289 [137594] automatically matched to d1xu9b_ complexed with nap, nn4 |
Domain d2irwc1: 2irw C:26-282 [137595] automatically matched to d1xu9b_ complexed with nap, nn4 |
Domain d2irwd1: 2irw D:26-289 [137596] automatically matched to d1xu9b_ complexed with nap, nn4 |
Domain d2irwe1: 2irw E:26-282 [137597] automatically matched to d1xu9b_ complexed with nap, nn4 |
Domain d2irwf1: 2irw F:26-289 [137598] automatically matched to d1xu9b_ complexed with nap, nn4 |
Domain d2irwg1: 2irw G:26-289 [137599] automatically matched to d1xu9b_ complexed with nap, nn4 |
Domain d2irwh1: 2irw H:26-289 [137600] automatically matched to d1xu9b_ complexed with nap, nn4 |
Domain d2rbea1: 2rbe A:25-284 [151846] automatically matched to d1xu9b_ complexed with ndp, zmg; mutant |
Domain d2rbeb1: 2rbe B:27-281 [151847] automatically matched to d1xu9b_ complexed with ndp, zmg; mutant |
Domain d2rbec1: 2rbe C:26-280 [151848] automatically matched to d1xu9b_ complexed with ndp, zmg; mutant |
Domain d2rbed1: 2rbe D:25-284 [151849] automatically matched to d1xu9b_ complexed with ndp, zmg; mutant |
Domain d3byza1: 3byz A:25-282 [155734] automatically matched to d1xu9b_ complexed with h11, ndp; mutant |
Domain d3byzb1: 3byz B:27-281 [155735] automatically matched to d1xu9b_ complexed with h11, ndp; mutant |
Domain d3byzc1: 3byz C:26-280 [155736] automatically matched to d1xu9b_ complexed with h11, ndp; mutant |
Domain d3byzd1: 3byz D:25-284 [155737] automatically matched to d1xu9b_ complexed with h11, ndp; mutant |
Domain d3bzua1: 3bzu A:25-287 [155788] automatically matched to d1xu9b_ complexed with a21, nap; mutant |
Domain d3bzub1: 3bzu B:25-283 [155789] automatically matched to d1xu9b_ complexed with a21, nap; mutant |
Domain d3bzuc1: 3bzu C:25-282 [155790] automatically matched to d1xu9b_ complexed with a21, nap; mutant |
Domain d3bzud1: 3bzu D:26-281 [155791] automatically matched to d1xu9b_ complexed with a21, nap; mutant |
Domain d3czra1: 3czr A:25-285 [157154] automatically matched to d1xu9b_ complexed with 3cz, cps, nap; mutant |
Domain d3czrb1: 3czr B:25-283 [157155] automatically matched to d1xu9b_ complexed with 3cz, cps, nap; mutant |
Domain d3d3ea1: 3d3e A:25-284 [157280] automatically matched to d1xu9b_ complexed with d3e, nap; mutant |
Domain d3d3eb1: 3d3e B:25-281 [157281] automatically matched to d1xu9b_ complexed with d3e, nap; mutant |
Domain d3d3ec1: 3d3e C:25-281 [157282] automatically matched to d1xu9b_ complexed with d3e, nap; mutant |
Domain d3d3ed1: 3d3e D:25-281 [157283] automatically matched to d1xu9b_ complexed with d3e, nap; mutant |
Domain d3d4na1: 3d4n A:25-282 [157296] automatically matched to d1xu9b_ complexed with d4n, nap; mutant |
Domain d3d4nb1: 3d4n B:25-284 [157297] automatically matched to d1xu9b_ complexed with d4n, nap; mutant |
Domain d3d4nc1: 3d4n C:25-281 [157298] automatically matched to d1xu9b_ complexed with d4n, nap; mutant |
Domain d3d4nd1: 3d4n D:25-281 [157299] automatically matched to d1xu9b_ complexed with d4n, nap; mutant |
Domain d3d5qa1: 3d5q A:25-287 [157399] automatically matched to d1xu9b_ complexed with nap, t30; mutant |
Domain d3d5qb1: 3d5q B:25-284 [157400] automatically matched to d1xu9b_ complexed with nap, t30; mutant |
Domain d3d5qc1: 3d5q C:25-281 [157401] automatically matched to d1xu9b_ complexed with nap, t30; mutant |
Domain d3d5qd1: 3d5q D:25-281 [157402] automatically matched to d1xu9b_ complexed with nap, t30; mutant |
Mouse (Mus musculus) [TaxId:10090] [141879] (2 PDB entries) Uniprot P50172 24-298 |
Domain d1y5ma1: 1y5m A:25-289 [122645] complexed with ndp, oct, so4 |
Domain d1y5mb1: 1y5m B:25-289 [122646] automatically matched to 1Y5M A:25-289 complexed with ndp, oct, so4 |
Domain d1y5ra1: 1y5r A:25-289 [122651] automatically matched to 1Y5M A:25-289 complexed with c0r, ndp |
Domain d1y5rb1: 1y5r B:25-289 [122652] automatically matched to 1Y5M A:25-289 complexed with c0r, ndp |
Timeline for Protein 11-beta-hydroxysteroid dehydrogenase 1 from c.2.1.2: Tyrosine-dependent oxidoreductases: