Lineage for Protein: 11-beta-hydroxysteroid dehydrogenase 1

  1. Root: SCOP 1.73
  2. 681097Class c: Alpha and beta proteins (a/b) [51349] (141 folds)
  3. 685975Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 685976Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families) (S)
  5. 686289Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 686319Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)

Species:

  1. 686320Guinea pig (Cavia porcellus) [TaxId:10141] [117425] (1 PDB entry)
  2. 686323Human (Homo sapiens) [TaxId:9606] [117424] (4 PDB entries)
    1. Domains for 1xu7:
      1. 686328Domain d1xu7a_: 1xu7 A: [116048]
      2. 686329Domain d1xu7b_: 1xu7 B: [116049]
      3. 686330Domain d1xu7c_: 1xu7 C: [116050]
      4. 686331Domain d1xu7d_: 1xu7 D: [116051]
        complexed with cps, ndp; mutant
    2. Domains for 1xu9:
      1. 686324Domain d1xu9a_: 1xu9 A: [116052]
      2. 686325Domain d1xu9b_: 1xu9 B: [116053]
      3. 686326Domain d1xu9c_: 1xu9 C: [116054]
      4. 686327Domain d1xu9d_: 1xu9 D: [116055]
        complexed with cps, mes, ndp; mutant
    3. Domains for 2bel:
      1. 686332Domain d2bela_: 2bel A: [116694]
      2. 686333Domain d2belb_: 2bel B: [116695]
      3. 686334Domain d2belc_: 2bel C: [116696]
      4. 686335Domain d2beld_: 2bel D: [116697]
        complexed with cbo, cl, nap
    4. Domains for 2irw:
      1. 686336Domain d2irwa1: 2irw A:26-289 [137593]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      2. 686337Domain d2irwb1: 2irw B:26-289 [137594]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      3. 686338Domain d2irwc1: 2irw C:26-282 [137595]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      4. 686339Domain d2irwd1: 2irw D:26-289 [137596]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      5. 686340Domain d2irwe1: 2irw E:26-282 [137597]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      6. 686341Domain d2irwf1: 2irw F:26-289 [137598]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      7. 686342Domain d2irwg1: 2irw G:26-289 [137599]
        automatically matched to d1xu9b_
        complexed with nap, nn4
      8. 686343Domain d2irwh1: 2irw H:26-289 [137600]
        automatically matched to d1xu9b_
        complexed with nap, nn4
  3. 686344Mouse (Mus musculus) [TaxId:10090] [141879] (2 PDB entries)
    1. Domains for 1y5m:
      1. 686345Domain d1y5ma1: 1y5m A:25-289 [122645]
        complexed with ndp, oct, so4
      2. 686346Domain d1y5mb1: 1y5m B:25-289 [122646]
        automatically matched to 1Y5M A:25-289
        complexed with ndp, oct, so4
    2. Domains for 1y5r:
      1. 686347Domain d1y5ra1: 1y5r A:25-289 [122651]
        automatically matched to 1Y5M A:25-289
        complexed with c0r, ndp
      2. 686348Domain d1y5rb1: 1y5r B:25-289 [122652]
        automatically matched to 1Y5M A:25-289
        complexed with c0r, ndp

More info for Protein 11-beta-hydroxysteroid dehydrogenase 1 from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein 11-beta-hydroxysteroid dehydrogenase 1 from c.2.1.2: Tyrosine-dependent oxidoreductases: