SCOPe 2.08: Domain d2belc1: 2bel C:26-271

Lineage for d2belc1 (2bel C:26-271)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
   has additional subdomain(s) that are not in the common domain
   

6. Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117424] (29 PDB entries)
   Uniprot P28845

8. Domain d2belc1: 2bel C:26-271 [116696]
   Other proteins in same PDB: d2belc2, d2beld2
   complexed with cbo, cl, nap

Details for d2belc1

PDB Entry: 2bel, 2.11 Å

PDB Description: structure of human 11-beta-hydroxysteroid dehydrogenase in complex with nadp and carbenoxolone

PDB Compounds: (C:) Corticosteroid 11-beta-dehydrogenase isozyme 1

SCOPe Domain Sequences for d2belc1:

Sequence, based on SEQRES records:

>d2belc1 c.2.1.2 (C:26-271) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]}
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslwtt
llirnp

Sequence, based on observed residues (ATOM records):

>d2belc1 c.2.1.2 (C:26-271) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]}
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavsgmqaapkeecaleiikggalrqeevyydsslwttlli
rnp

Timeline for d2belc1:

• d2belc1 first appeared in SCOP 1.71, called d2belc_
  
• d2belc1 appears in SCOPe 2.07