SCOP 1.73: Domain d1yb1b_: 1yb1 B:

Lineage for d1yb1b_ (1yb1 B:)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein 17-beta-hydroxysteroid dehydrogenase type XI [117426] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117427] (1 PDB entry)

8. Domain d1yb1b_: 1yb1 B: [116600]
   Structural genomics target
   complexed with ae2, cl, gol, so4

Details for d1yb1b_

PDB Entry: 1yb1, 1.95 Å

PDB Description: crystal structure of human 17-beta-hydroxysteroid dehydrogenase type xi

PDB Compounds: (B:) 17-beta-hydroxysteroid dehydrogenase type XI

SCOP Domain Sequences for d1yb1b_:

Sequence, based on SEQRES records:

>d1yb1b_ c.2.1.2 (B:) 17-beta-hydroxysteroid dehydrogenase type XI {Human (Homo sapiens) [TaxId: 9606]}
rrksvtgeivlitgaghgigrltayefaklksklvlwdinkhgleetaakckglgakvht
fvvdcsnrediyssakkvkaeigdvsilvnnagvvytsdlfatqdpqiektfevnvlahf
wttkaflpamtknnhghivtvasaaghvsvpfllaycsskfaavgfhktltdelaalqit
gvkttclcpnfvntgfiknpstslgptlepeevvnrlmhgilteqkmifipssiaflttl
eril

Sequence, based on observed residues (ATOM records):

>d1yb1b_ c.2.1.2 (B:) 17-beta-hydroxysteroid dehydrogenase type XI {Human (Homo sapiens) [TaxId: 9606]}
rrksvtgeivlitgaghgigrltayefaklksklvlwdinkhgleetaakckglgakvht
fvvdcsnrediyssakkvkaeigdvsilvnnagvvytsdlfatqdpqiektfevnvlahf
wttkaflpamtknnhghivtvasahvsvpfllaycsskfaavgfhktltdelaalqitgv
kttclcpnfvntgfiknpstslgptlepeevvnrlmhgilteqkmifipssiaflttler
il

Timeline for d1yb1b_:

• d1yb1b_ first appeared in SCOP 1.71
  
• d1yb1b_ appears in SCOP 1.75
  
• d1yb1b_ appears in the current release, SCOPe 2.08