SCOPe 2.07: Domain d1yb1a_: 1yb1 A:

Lineage for d1yb1a_ (1yb1 A:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein 17-beta-hydroxysteroid dehydrogenase type XI [117426] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117427] (1 PDB entry)
   Uniprot Q8NBQ5 30-273

8. Domain d1yb1a_: 1yb1 A: [116599]
   Structural genomics target
   complexed with aoi, cl, gol, so4

Details for d1yb1a_

PDB Entry: 1yb1, 1.95 Å

PDB Description: crystal structure of human 17-beta-hydroxysteroid dehydrogenase type xi

PDB Compounds: (A:) 17-beta-hydroxysteroid dehydrogenase type XI

SCOPe Domain Sequences for d1yb1a_:

Sequence, based on SEQRES records:

>d1yb1a_ c.2.1.2 (A:) 17-beta-hydroxysteroid dehydrogenase type XI {Human (Homo sapiens) [TaxId: 9606]}
rrksvtgeivlitgaghgigrltayefaklksklvlwdinkhgleetaakckglgakvht
fvvdcsnrediyssakkvkaeigdvsilvnnagvvytsdlfatqdpqiektfevnvlahf
wttkaflpamtknnhghivtvasaaghvsvpfllaycsskfaavgfhktltdelaalqit
gvkttclcpnfvntgfiknpstslgptlepeevvnrlmhgilteqkmifipssiaflttl
eril

Sequence, based on observed residues (ATOM records):

>d1yb1a_ c.2.1.2 (A:) 17-beta-hydroxysteroid dehydrogenase type XI {Human (Homo sapiens) [TaxId: 9606]}
rrksvtgeivlitgaghgigrltayefaklksklvlwdinkhgleetaakckglgakvht
fvvdcsnrediyssakkvkaeigdvsilvnnagvvytsdlfatqdpqiektfevnvlahf
wttkaflpamtknnhghivtvasaahvsvpfllaycsskfaavgfhktltdelaalqitg
vkttclcpnfvntgfiknpstslgptlepeevvnrlmhgilteqkmifipssiaflttle
ril

Timeline for d1yb1a_:

• d1yb1a_ first appeared in SCOP 1.71
  
• d1yb1a_ appears in SCOPe 2.06
  
• d1yb1a_ appears in the current release, SCOPe 2.08