SCOP 1.71: Domain d1xu9d_: 1xu9 D:

Lineage for d1xu9d_ (1xu9 D:)

1. Root: SCOP 1.71

2. Class c: Alpha and beta proteins (a/b) [51349] (134 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (53 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117424] (3 PDB entries)

8. Domain d1xu9d_: 1xu9 D: [116055]
   complexed with cps, mes, ndp; mutant

Details for d1xu9d_

PDB Entry: 1xu9, 1.55 Å

PDB Description: crystal structure of the interface closed conformation of 11b- hydroxysteroid dehydrogenase isozyme 1

SCOP Domain Sequences for d1xu9d_:

Sequence, based on SEQRES records:

>d1xu9d_ c.2.1.2 (D:) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens)}
qqplneefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshcl
elgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrks
mevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirk
eysvsrvnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyyd
sslwttllirnpsrkileflys

Sequence, based on observed residues (ATOM records):

>d1xu9d_ c.2.1.2 (D:) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens)}
qqplneefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshcl
elgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrks
mevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirk
eysvsrvnvsitlcvlglidtetamkavsmqaapkeecaleiikggalrqeevyydsslw
ttllirnpsrkileflys

Timeline for d1xu9d_:

• d1xu9d_ is new in SCOP 1.71
  
• d1xu9d_ appears in SCOP 1.73
  
• d1xu9d_ appears in the current release, SCOPe 2.08, called d1xu9d1