SCOPe 2.06: Domain d1xtfa1: 1xtf A:2-422

Lineage for d1xtfa1 (1xtf A:2-422)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families)

5. Family d.92.1.7: Clostridium neurotoxins, catalytic domain [55512] (2 proteins)

6. Protein Botulinum neurotoxin [55513] (4 species)

7. Species Clostridium botulinum, serotype A [TaxId:1491] [55514] (26 PDB entries)
   Uniprot P10845 1-419

8. Domain d1xtfa1: 1xtf A:2-422 [116018]
   Other proteins in same PDB: d1xtfa2, d1xtfb2
   complexed with zn; mutant

Details for d1xtfa1

PDB Entry: 1xtf, 2.2 Å

PDB Description: neurotoxin bont/a e224q y366f mutant

PDB Compounds: (A:) Neurotoxin BoNT/A

SCOPe Domain Sequences for d1xtfa1:

Sequence; same for both SEQRES and ATOM records:

>d1xtfa1 d.92.1.7 (A:2-422) Botulinum neurotoxin {Clostridium botulinum, serotype A [TaxId: 1491]}
pfvnkqfnykdpvngvdiayikipnagqmqpvkafkihnkiwviperdtftnpeegdlnp
ppeakqvpvsyydstylstdnekdnylkgvtklferiystdlgrmlltsivrgipfwggs
tidtelkvidtncinviqpdgsyrseelnlviigpsadiiqfecksfghevlnltrngyg
stqyirfspdftfgfeeslevdtnpllgagkfatdpavtlahqlihaghrlygiainpnr
vfkvntnayyemsglevsfeelrtfgghdakfidslqenefrlyyynkfkdiastlnkak
sivgttaslqymknvfkekyllsedtsgkfsvdklkfdklykmlteiytednfvkffkvl
nrktflnfdkavfkinivpkvnytiydgfnlrntnlaanfngqnteinnmnftklknftp
g

Timeline for d1xtfa1:

• d1xtfa1 first appeared in SCOP 1.71, called d1xtfa_
  
• d1xtfa1 was called d1xtfa_ in SCOPe 2.05
  
• d1xtfa1 appears in SCOPe 2.07
  
• d1xtfa1 appears in the current release, SCOPe 2.08