SCOP 1.75: Domain d1xseb_: 1xse B:

Lineage for d1xseb_ (1xse B:)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)

7. Species Guinea pig (Cavia porcellus) [TaxId:10141] [117425] (1 PDB entry)
   Uniprot Q6QLL4 23-296

8. Domain d1xseb_: 1xse B: [115926]
   complexed with ndp

Details for d1xseb_

PDB Entry: 1xse, 2.5 Å

PDB Description: crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1

PDB Compounds: (B:) 11beta-hydroxysteroid dehydrogenase type 1

SCOP Domain Sequences for d1xseb_:

Sequence; same for both SEQRES and ATOM records:

>d1xseb_ c.2.1.2 (B:) 11-beta-hydroxysteroid dehydrogenase 1 {Guinea pig (Cavia porcellus) [TaxId: 10141]}
nekfrpemlqgkkvivtgaskgigreiayhlakmgahvvvtarskealqkvvarclelga
asahyiagsmedmtfaeefvaeagnlmggldmlilnhvlynrltffhgeidnvrksmevn
fhsfvvlsvaampmlmqsqgsiavvssvagkitypliapysaskfaldgffstlrseflv
nkvnvsitlcilglidtetaikatsgiylgpaspkeecaleiikgtalrqdemyyvgsrw
vpyllgnpgrkimeflsaaeynwdnvlsneklyg

Timeline for d1xseb_:

• d1xseb_ first appeared in SCOP 1.71
  
• d1xseb_ appears in SCOP 1.73
  
• d1xseb_ appears in SCOPe 2.01
  
• d1xseb_ appears in the current release, SCOPe 2.08