SCOPe 2.06: Domain d1xotb_: 1xot B:

Lineage for d1xotb_ (1xot B:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b [48549] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48550] (30 PDB entries)
   Uniprot Q07343 324-667

8. Domain d1xotb_: 1xot B: [115714]
   complexed with mg, vdn, zn

Details for d1xotb_

PDB Entry: 1xot, 2.34 Å

PDB Description: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Vardenafil

PDB Compounds: (B:) cAMP-specific 3',5'-cyclic phosphodiesterase 4B

SCOPe Domain Sequences for d1xotb_:

Sequence; same for both SEQRES and ATOM records:

>d1xotb_ a.211.1.2 (B:) Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b {Human (Homo sapiens) [TaxId: 9606]}
edhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfrissdtfitymmt
ledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaaaihdvdhpgvs
nqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqrqtlrkmvidmv
latdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhcadlsnptkslel
yrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyivhplwetwadlv
qpdaqdildtlednrnwyqsmip

Timeline for d1xotb_:

• d1xotb_ first appeared in SCOP 1.71
  
• d1xotb_ appears in SCOPe 2.05
  
• d1xotb_ appears in SCOPe 2.07
  
• d1xotb_ appears in the current release, SCOPe 2.08