Lineage for d1xkka_ (1xkk A:)

  1. Root: SCOPe 2.07
  2. 2530962Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2586062Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2586063Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2586210Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2587580Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
    PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase
  7. 2587581Species Human (Homo sapiens) [TaxId:9606] [82796] (129 PDB entries)
    Uniprot P00533 702-1018
  8. 2587622Domain d1xkka_: 1xkk A: [115409]
    complexed with fmm, po4

Details for d1xkka_

PDB Entry: 1xkk (more details), 2.4 Å

PDB Description: EGFR kinase domain complexed with a quinazoline inhibitor- GW572016
PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d1xkka_:

Sequence, based on SEQRES records: (download)

>d1xkka_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
allrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeild
eayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqi
akgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpikwm
alesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppicti
dvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyral
mdeedmddvvdadeyli

Sequence, based on observed residues (ATOM records): (download)

>d1xkka_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
allrilketefkkikvlgsgafgtvykglwipvkipvaikelrekankeildeayvmasv
dnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqiakgmnyle
drrlvhrdlaarnvlvktpqhvkitdfglakllgaeekvpikwmalesilhriythqsdv
wsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvkcwmidads
rpkfreliiefskmardpqrylviqgdermsnfyralmdevvdadeyli

SCOPe Domain Coordinates for d1xkka_:

Click to download the PDB-style file with coordinates for d1xkka_.
(The format of our PDB-style files is described here.)

Timeline for d1xkka_: