SCOPe 2.08: Domain d1xf9a_: 1xf9 A:

Lineage for d1xf9a_ (1xf9 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.12: ABC transporter ATPase domain-like [52686] (25 proteins)
   there are two additional subdomains inserted into the central core that has a RecA-like topology
   missing some secondary structures that made up less than one-third of the common domain
   

6. Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain [102378] (2 species)

7. Species Mouse (Mus musculus) [TaxId:10090] [102379] (9 PDB entries)
   Uniprot P26361 390-670

8. Domain d1xf9a_: 1xf9 A: [115245]
   Other proteins in same PDB: d1xf9c2
   complexed with acy, atp, mg; mutant

Details for d1xf9a_

PDB Entry: 1xf9, 2.7 Å

PDB Description: structure of nbd1 from murine cftr- f508s mutant

PDB Compounds: (A:) Cystic fibrosis transmembrane conductance regulator

SCOPe Domain Sequences for d1xf9a_:

Sequence, based on SEQRES records:

>d1xf9a_ c.37.1.12 (A:) Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain {Mouse (Mus musculus) [TaxId: 10090]}
tgiimenvtafweegfgellekvqqsngdrkhssdennvsfshlclvgnpvlkninlnie
kgemlaitgstgsgktsllmlilgeleasegiikhsgrvsfcsqfswimpgtikeniisg
vsydeyryksvvkacqlqqditkfaeqdntvlgeggvtlsggqrarislaravykdadly
lldspfgyldvfteeqvfescvcklmanktrilvtskmehlrkadkililhqgssyfygt
fselqslrpdfssklmgydtfdqfteerrssiltetlrrfs

Sequence, based on observed residues (ATOM records):

>d1xf9a_ c.37.1.12 (A:) Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain {Mouse (Mus musculus) [TaxId: 10090]}
tgiimenvtafweegfgelleksfshlclvgnpvlkninlniekgemlaitgstgsgkts
llmlilgeleasegiikhsgrvsfcsqfswimpgtikeniisgvsydeyryksvvkacql
qqditkfaeqdntvlgeggvtlsggqrarislaravykdadlylldspfgyldvfteeqv
fescvcklmanktrilvtskmehlrkadkililhqgssyfygtfselqslrpdfssklmg
ydtfdqfteerrssiltetlrrfs

Timeline for d1xf9a_:

• d1xf9a_ first appeared in SCOP 1.71
  
• d1xf9a_ appears in SCOPe 2.07