SCOP 1.75: Domain d1xdke_: 1xdk E:

Lineage for d1xdke_ (1xdk E:)

1. Root: SCOP 1.75

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (1 family)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (33 proteins)

6. Protein Retinoid-X receptor alpha (RXR-alpha) [48510] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48511] (18 PDB entries)
   Uniprot P19793 227-458

8. Domain d1xdke_: 1xdk E: [115166]
   Other proteins in same PDB: d1xdkb_, d1xdkf_
   complexed with co-activator peptide
   complexed with rea

Details for d1xdke_

PDB Entry: 1xdk, 2.9 Å

PDB Description: crystal structure of the rarbeta/rxralpha ligand binding domain heterodimer in complex with 9-cis retinoic acid and a fragment of the trap220 coactivator

PDB Compounds: (E:) Retinoic acid receptor RXR-alpha

SCOP Domain Sequences for d1xdke_:

Sequence, based on SEQRES records:

>d1xdke_ a.123.1.1 (E:) Retinoid-X receptor alpha (RXR-alpha) {Human (Homo sapiens) [TaxId: 9606]}
anedmpvekileaelavepktetyveanmglnpsspndpvtnicqaadkqlftlvewakr
iphfselplddqvillragwnelliasfshrsiavkdgillatglhvhrnsahsagvgai
fdrvltelvskmrdmqmdktelgclraivlfnpdskglsnpaevealrekvyasleayck
hkypeqpgrfaklllrlpalrsiglkclehlfffkligdtpidtflmemleap

Sequence, based on observed residues (ATOM records):

>d1xdke_ a.123.1.1 (E:) Retinoid-X receptor alpha (RXR-alpha) {Human (Homo sapiens) [TaxId: 9606]}
anedmpvekileaelaveppndpvtnicqaadkqlftlvewakriphfselplddqvill
ragwnelliasfshrsiavkdgillatglhvhrnsahsagvgaifdrvltelvskmrdmq
mdktelgclraivlfnpdskglsnpaevealrekvyasleayckhkypeqpgrfaklllr
lpalrsiglkclehlfffkligdtpidtflmemleap

Timeline for d1xdke_:

• d1xdke_ first appeared in SCOP 1.71
  
• d1xdke_ appears in SCOP 1.73
  
• d1xdke_ appears in SCOPe 2.01
  
• d1xdke_ appears in the current release, SCOPe 2.08