SCOPe 2.08: Domain d1xdib1: 1xdi B:2-161,B:276-348

Lineage for d1xdib1 (1xdi B:2-161,B:276-348)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.3: FAD/NAD(P)-binding domain [51904] (1 superfamily)
   core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander

4. Superfamily c.3.1: FAD/NAD(P)-binding domain [51905] (9 families)

5. Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains [51943] (25 proteins)
   duplication: both domains have similar folds and functions
   most members of the family contain common C-terminal alpha+beta domain

6. Protein Dihydrolipoamide dehydrogenase, N- and C-terminal domain [418938] (8 species)

7. Species Mycobacterium tuberculosis [TaxId:1773] [117441] (1 PDB entry)
   Uniprot O53355

8. Domain d1xdib1: 1xdi B:2-161,B:276-348 [115162]
   Other proteins in same PDB: d1xdia2, d1xdib2
   complexed with fad
   has additional insertions and/or extensions that are not grouped together

Details for d1xdib1

PDB Entry: 1xdi, 2.81 Å

PDB Description: Crystal structure of LpdA (Rv3303c) from Mycobacterium tuberculosis

PDB Compounds: (B:) Rv3303c-lpdA

SCOPe Domain Sequences for d1xdib1:

Sequence, based on SEQRES records:

>d1xdib1 c.3.1.5 (B:2-161,B:276-348) Dihydrolipoamide dehydrogenase, N- and C-terminal domain {Mycobacterium tuberculosis [TaxId: 1773]}
vtrivilgggpagyeaalvaatshpettqvtvidcdgiggaavlddcvpsktfiastglr
telrraphlgfhidfddakislpqiharvktlaaaqsaditaqllsmgvqviagrgelid
stpglarhrikataadgstseheadvvlvatgasprilpsXgsvpntsglglervgiqlg
rgnyltvdrvsrtlatgiyaagdctgllplasvaamqgriamyhalgegvspir

Sequence, based on observed residues (ATOM records):

>d1xdib1 c.3.1.5 (B:2-161,B:276-348) Dihydrolipoamide dehydrogenase, N- and C-terminal domain {Mycobacterium tuberculosis [TaxId: 1773]}
vtrivilgggpagyeaalvaatshpettqvtvidcdgiggaavlddcvpsktfiastglr
telrraphlgfhkislpqiharvktlaaaqsaditaqllsmgvqviagrgelidstpgla
rhrikataadgstseheadvvlvatgasprilpsXgsvpntsglglervgiqlgrgnylt
vdrvsrtlatgiyaagdctgllplasvaamqgriamyhalgegvspir

Timeline for d1xdib1:

• d1xdib1 first appeared in SCOP 1.71
  
• d1xdib1 appears in SCOPe 2.07