SCOPe 2.06: Domain d1xdia1: 1xdi A:2-161,A:276-348

Lineage for d1xdia1 (1xdi A:2-161,A:276-348)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.3: FAD/NAD(P)-binding domain [51904] (1 superfamily)
   core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander

4. Superfamily c.3.1: FAD/NAD(P)-binding domain [51905] (9 families)

5. Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains [51943] (15 proteins)
   duplication: both domains have similar folds and functions
   most members of the family contain common C-terminal alpha+beta domain

6. Protein Dihydrolipoamide dehydrogenase [51959] (8 species)

7. Species Mycobacterium tuberculosis [TaxId:1773] [117441] (1 PDB entry)
   Uniprot O53355

8. Domain d1xdia1: 1xdi A:2-161,A:276-348 [115160]
   Other proteins in same PDB: d1xdia2, d1xdib2
   complexed with fad

Details for d1xdia1

PDB Entry: 1xdi, 2.81 Å

PDB Description: Crystal structure of LpdA (Rv3303c) from Mycobacterium tuberculosis

PDB Compounds: (A:) Rv3303c-lpdA

SCOPe Domain Sequences for d1xdia1:

Sequence, based on SEQRES records:

>d1xdia1 c.3.1.5 (A:2-161,A:276-348) Dihydrolipoamide dehydrogenase {Mycobacterium tuberculosis [TaxId: 1773]}
vtrivilgggpagyeaalvaatshpettqvtvidcdgiggaavlddcvpsktfiastglr
telrraphlgfhidfddakislpqiharvktlaaaqsaditaqllsmgvqviagrgelid
stpglarhrikataadgstseheadvvlvatgasprilpsXgsvpntsglglervgiqlg
rgnyltvdrvsrtlatgiyaagdctgllplasvaamqgriamyhalgegvspir

Sequence, based on observed residues (ATOM records):

>d1xdia1 c.3.1.5 (A:2-161,A:276-348) Dihydrolipoamide dehydrogenase {Mycobacterium tuberculosis [TaxId: 1773]}
vtrivilgggpagyeaalvaatshpettqvtvidcdgiggaavlddcvpsktfiastglr
telrraphlgfhkislpqiharvktlaaaqsaditaqllsmgvqviagrgelidstpgla
rhrikataadgstseheadvvlvatgasprilpsXgsvpntsglglervgiqlgrgnylt
vdrvsrtlatgiyaagdctgllplasvaamqgriamyhalgegvspir

Timeline for d1xdia1:

• d1xdia1 first appeared in SCOP 1.71
  
• d1xdia1 appears in SCOPe 2.05
  
• d1xdia1 appears in SCOPe 2.07
  
• d1xdia1 appears in the current release, SCOPe 2.08