SCOPe 2.08: Domain d1xcge2: 1xcg E:942-1081

Lineage for d1xcge2 (1xcg E:942-1081)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.55: PH domain-like barrel [50728] (3 superfamilies)
   barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix

4. Superfamily b.55.1: PH domain-like [50729] (14 families)

5. Family b.55.1.1: Pleckstrin-homology domain (PH domain) [50730] (48 proteins)
   Pfam PF00169

6. Protein Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF [117254] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117255] (5 PDB entries)
   Uniprot O15085 714-1081

8. Domain d1xcge2: 1xcg E:942-1081 [115124]
   Other proteins in same PDB: d1xcga1, d1xcgb_, d1xcge1, d1xcgf_

Details for d1xcge2

PDB Entry: 1xcg, 2.5 Å

PDB Description: crystal structure of human rhoa in complex with dh/ph fragment of pdzrhogef

PDB Compounds: (E:) Rho guanine nucleotide exchange factor 11

SCOPe Domain Sequences for d1xcge2:

Sequence, based on SEQRES records:

>d1xcge2 b.55.1.1 (E:942-1081) Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF {Human (Homo sapiens) [TaxId: 9606]}
atalerasnplaaefksldlttrkmihegpltwriskdktldlhvllledllvllqkqde
klllkchsktavgssdskqtfspvlklnavlirsvatdkraffiictsklgppqiyelva
ltssdkntwmelleeavrna

Sequence, based on observed residues (ATOM records):

>d1xcge2 b.55.1.1 (E:942-1081) Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF {Human (Homo sapiens) [TaxId: 9606]}
atalerasnplaaefksldlttrkmihegpltwriskdktldlhvllledllvllqkqde
klllkchsktfspvlklnavlirsvatdkraffiictsklgppqiyelvaltssdkntwm
elleeavrna

Timeline for d1xcge2:

• d1xcge2 first appeared in SCOP 1.71
  
• d1xcge2 appears in SCOPe 2.07