Lineage for d1x7yb1 (1x7y B:14-204)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2108258Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 2108259Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 2108430Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (5 protein domains)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
    automatically mapped to Pfam PF02779
  6. 2108434Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module [88742] (2 species)
  7. 2108435Species Human (Homo sapiens) [TaxId:9606] [88743] (23 PDB entries)
    Uniprot P21953 52-392
  8. 2108438Domain d1x7yb1: 1x7y B:14-204 [114945]
    Other proteins in same PDB: d1x7ya_, d1x7yb2
    complexed with cl, gol, k, mn, tdp

Details for d1x7yb1

PDB Entry: 1x7y (more details), 1.57 Å

PDB Description: Crystal structure of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase
PDB Compounds: (B:) 2-oxoisovalerate dehydrogenase beta subunit

SCOPe Domain Sequences for d1x7yb1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1x7yb1 c.36.1.7 (B:14-204) Branched-chain alpha-keto acid dehydrogenase, Pyr module {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1x7yb1:

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Timeline for d1x7yb1:

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