SCOPe 2.07: Domain d1w8dd_: 1w8d D:

Lineage for d1w8dd_ (1w8d D:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein 2,4-dienoyl-CoA reductase, mitochondrial (DECR) [117421] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117422] (3 PDB entries)
   Uniprot Q16698 35-328

8. Domain d1w8dd_: 1w8d D: [114367]
   complexed with gol, nap

Details for d1w8dd_

PDB Entry: 1w8d, 2.2 Å

PDB Description: binary structure of human decr.

PDB Compounds: (D:) 2,4-dienoyl-coa reductase, mitochondrial precursor

SCOPe Domain Sequences for d1w8dd_:

Sequence, based on SEQRES records:

>d1w8dd_ c.2.1.2 (D:) 2,4-dienoyl-CoA reductase, mitochondrial (DECR) {Human (Homo sapiens) [TaxId: 9606]}
mntealqskffsplqkamlppnsfqgkvafitgggtglgkgmttllsslgaqcviasrkm
dvlkataeqissqtgnkvhaiqcdvrdpdmvqntvselikvaghpnivinnaagnfispt
erlspnawktitdivlngtafvtleigkqlikaqkgaaflsittiyaetgsgfvvpsasa
kagveamskslaaewgkygmrfnviqpgpiktkgafsrldptgtfekemigripcgrlgt
veelanlaaflcsdyaswingavikfdggeevlisgefndlrkvtkeqwdtiee

Sequence, based on observed residues (ATOM records):

>d1w8dd_ c.2.1.2 (D:) 2,4-dienoyl-CoA reductase, mitochondrial (DECR) {Human (Homo sapiens) [TaxId: 9606]}
mntealqskffsplqkamlppnsfqgkvafitgggtglgkgmttllsslgaqcviasrkm
dvlkataeqissqtgnkvhaiqcdvrdpdmvqntvselikvaghpnivinnaagnfispt
erlspnawktitdivlngtafvtleigkqlikaqkgaaflsittiyaetgsgfvvpsasa
kagveamskslaaewgkygmrfnviqpgpiktkemigripcgrlgtveelanlaaflcsd
yaswingavikfdggeevlisgefndlrkvtkeqwdtiee

Timeline for d1w8dd_:

• d1w8dd_ first appeared in SCOP 1.71
  
• d1w8dd_ appears in SCOPe 2.06
  
• d1w8dd_ appears in the current release, SCOPe 2.08