Lineage for d1w85h1 (1w85 H:1-192)

  1. Root: SCOPe 2.08
  2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (5 proteins)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
    automatically mapped to Pfam PF02779
  6. Protein Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain [117522] (1 species)
  7. Species Bacillus stearothermophilus [TaxId:1422] [117523] (2 PDB entries)
    Uniprot P21874
  8. Domain d1w85h1: 1w85 H:1-192 [114345]
    Other proteins in same PDB: d1w85a_, d1w85b2, d1w85c_, d1w85d2, d1w85e_, d1w85f2, d1w85g_, d1w85h2, d1w85i_, d1w85j_
    complexed with k, mg, peg, tdp

Details for d1w85h1

PDB Entry: 1w85 (more details), 2 Å

PDB Description: the crystal structure of pyruvate dehydrogenase e1 bound to the peripheral subunit binding domain of e2
PDB Compounds: (H:) pyruvate dehydrogenase e1 component, beta subunit

SCOPe Domain Sequences for d1w85h1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1w85h1 c.36.1.7 (H:1-192) Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain {Bacillus stearothermophilus [TaxId: 1422]}

SCOPe Domain Coordinates for d1w85h1 are not available.

Timeline for d1w85h1:

Domains from same chain:
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Domains from other chains:
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d1w85a_, d1w85b1, d1w85b2, d1w85c_, d1w85d1, d1w85d2, d1w85e_, d1w85f1, d1w85f2, d1w85g_, d1w85i_, d1w85j_