Lineage for d1w85e_ (1w85 E:)

  1. Root: SCOP 1.71
  2. 570216Class c: Alpha and beta proteins (a/b) [51349] (134 folds)
  3. 581036Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 581037Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 581340Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (4 proteins)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
  6. 581373Protein Pyruvate dehydrogenase E1-alpha, PdhA [117525] (1 species)
  7. 581374Species Bacillus stearothermophilus [TaxId:1422] [117526] (2 PDB entries)
  8. 581381Domain d1w85e_: 1w85 E: [114341]
    Other proteins in same PDB: d1w85b1, d1w85b2, d1w85d1, d1w85d2, d1w85f1, d1w85f2, d1w85h1, d1w85h2, d1w85i_, d1w85j_

Details for d1w85e_

PDB Entry: 1w85 (more details), 2 Å

PDB Description: the crystal structure of pyruvate dehydrogenase e1 bound to the peripheral subunit binding domain of e2

SCOP Domain Sequences for d1w85e_:

Sequence, based on SEQRES records: (download)

>d1w85e_ c.36.1.11 (E:) Pyruvate dehydrogenase E1-alpha, PdhA {Bacillus stearothermophilus}
fqfpfaeqlekvaeqfptfqilneegevvneeampelsdeqlkelmrrmvytrildqrsi
slnrqgrlgfyaptagqeasqiashfalekedfilpgyrdvpqiiwhglplyqaflfsrg
hfhgnqipegvnvlppqiiigaqyiqaagvalglkmrgkkavaitytgdggtsqgdfyeg
infagafkapaifvvqnnrfaistpvekqtvaktlaqkavaagipgiqvdgmdplavyaa
vkaareraingegptlietlcfrygphtmsgddptryrskelenewakkdplvrfrkfle
akglwseeeennvieqakeeikeaikkadetpkqkvtdlisimfeelpfnlkeqyeiyke
kesk

Sequence, based on observed residues (ATOM records): (download)

>d1w85e_ c.36.1.11 (E:) Pyruvate dehydrogenase E1-alpha, PdhA {Bacillus stearothermophilus}
fqfpfaeqlekvaeqfptfqilneegevvneeampelsdeqlkelmrrmvytrildqrsi
slnrqgrlgfyaptagqeasqiashfalekedfilpgyrdvpqiiwhglplyqaflfsrg
hfhgnqipegvnvlppqiiigaqyiqaagvalglkmrgkkavaitytgdggtsqgdfyeg
infagafkapaifvvqnnrkqtvaktlaqkavaagipgiqvdgmdplavyaavkaarera
ingegptlietlcfrygphtmsgddkelenewakkdplvrfrkfleakglwseeeennvi
eqakeeikeaikkadetpkqkvtdlisimfeelpfnlkeqyeiykekesk

SCOP Domain Coordinates for d1w85e_:

Click to download the PDB-style file with coordinates for d1w85e_.
(The format of our PDB-style files is described here.)

Timeline for d1w85e_: