SCOP 1.73: Domain d1w6ud_: 1w6u D:

Lineage for d1w6ud_ (1w6u D:)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein 2,4-dienoyl-CoA reductase, mitochondrial (DECR) [117421] (1 species)

7. Species Human (Homo sapiens), [TaxId:9606] [117422] (3 PDB entries)

8. Domain d1w6ud_: 1w6u D: [114291]
   complexed with hxc, nap

Details for d1w6ud_

PDB Entry: 1w6u, 1.75 Å

PDB Description: structure of human decr ternary complex

PDB Compounds: (D:) 2,4-dienoyl-coa reductase,mitochondrial precursor

SCOP Domain Sequences for d1w6ud_:

Sequence, based on SEQRES records:

>d1w6ud_ c.2.1.2 (D:) 2,4-dienoyl-CoA reductase, mitochondrial (DECR) {Human (Homo sapiens), [TaxId: 9606]}
mntealqskffsplqkamlppnsfqgkvafitgggtglgkgmttllsslgaqcviasrkm
dvlkataeqissqtgnkvhaiqcdvrdpdmvqntvselikvaghpnivinnaagnfispt
erlspnawktitdivlngtafvtleigkqlikaqkgaaflsittiyaetgsgfvvpsasa
kagveamskslaaewgkygmrfnviqpgpiktkgafsrldptgtfekemigripcgrlgt
veelanlaaflcsdyaswingavikfdggeevlisgefndlrkvtkeqwdtiee

Sequence, based on observed residues (ATOM records):

>d1w6ud_ c.2.1.2 (D:) 2,4-dienoyl-CoA reductase, mitochondrial (DECR) {Human (Homo sapiens), [TaxId: 9606]}
mntealqskffsplqkamlppnsfqgkvafitgggtglgkgmttllsslgaqcviasrkm
dvlkataeqissqtgnkvhaiqcdvrdpdmvqntvselikvaghpnivinnaagnfispt
erlspnawktitdivlngtafvtleigkqlikaqkgaaflsittiyaetgsgfvvpsasa
kagveamskslaaewgkygmrfnviqpgpiktfekemigripcgrlgtveelanlaaflc
sdyaswingavikfdggeevlisgefndlrkvtkeqwdtiee

Timeline for d1w6ud_:

• d1w6ud_ first appeared in SCOP 1.71
  
• d1w6ud_ appears in SCOP 1.75
  
• d1w6ud_ appears in the current release, SCOPe 2.08