SCOPe 2.08: Domain d1w6ka1: 1w6k A:6-99,A:379-732

Lineage for d1w6ka1 (1w6k A:6-99,A:379-732)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.102: alpha/alpha toroid [48207] (6 superfamilies)
   multihelical; up to seven alpha-hairpins are arranged in closed circular array; there may be sequence similarities between different superfamilies

4. Superfamily a.102.4: Terpenoid cyclases/Protein prenyltransferases [48239] (5 families)

5. Family a.102.4.2: Terpene synthases [48243] (3 proteins)
   consists of two toroid domains: one of six and one of five hairpins

6. Protein Lanosterol synthase, N- and C-terminal domain [418898] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [419298] (2 PDB entries)
   Uniprot P48449

8. Domain d1w6ka1: 1w6k A:6-99,A:379-732 [114271]
   Other proteins in same PDB: d1w6ka2
   complexed with bog, lan
   has additional insertions and/or extensions that are not grouped together

Details for d1w6ka1

PDB Entry: 1w6k, 2.1 Å

PDB Description: structure of human osc in complex with lanosterol

PDB Compounds: (A:) lanosterol synthase

SCOPe Domain Sequences for d1w6ka1:

Sequence, based on SEQRES records:

>d1w6ka1 a.102.4.2 (A:6-99,A:379-732) Lanosterol synthase, N- and C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
clrrrggpyktepatdlgrwrlncergrqtwtylqderagreqtgleayalgldtknyfk
dlpkahtafegalngmtfyvglqaedghwtgdygXqgtngsqiwdtafaiqalleagghh
rpefssclqkaheflrlsqvpdnppdyqkyyrqmrkggfsfstldcgwivsdctaealka
vlllqekcphvtehiprerlcdavavllnmrnpdggfatyetkrgghllellnpsevfgd
imidytyvectsavmqalkyfhkrfpehraaeiretltqglefcrrqqradgswegswgv
cftygtwfgleafacmgqtyrdgtacaevsracdfllsrqmadggwgedfesceerryvq
saqsqihntcwammglmavrhpdieaqergvrcllekqlpngdwpqeniagvfnkscais
ytsyrnifpiwalgrfsqlyperalaghp

Sequence, based on observed residues (ATOM records):

>d1w6ka1 a.102.4.2 (A:6-99,A:379-732) Lanosterol synthase, N- and C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
clrrrggpyktepatdlgrwrlncergrqtwtylqdagreqtgleayalgldtknyfkdl
pkahtafegalngmtfyvglqaedghwtgdygXqgtngsqiwdtafaiqalleagghhrp
efssclqkaheflrlsqvpdnppdyqkyyrqmrkggfsfstldcgwivsdctaealkavl
llqekcphvtehiprerlcdavavllnmrnpdggfatyetkrgghllellnpsevfgdim
idytyvectsavmqalkyfhkrfpehraaeiretltqglefcrrqqradgswegswgvcf
tygtwfgleafacmgqtyrdgtacaevsracdfllsrqmadggwgedfesceerryvqsa
qsqihntcwammglmavrhpdieaqergvrcllekqlpngdwpqeniagvfnkscaisyt
syrnifpiwalgrfsqlyperalaghp

Timeline for d1w6ka1:

• d1w6ka1 first appeared in SCOP 1.71
  
• d1w6ka1 appears in SCOPe 2.07