SCOPe 2.08: Domain d1w4zb1: 1w4z B:1-261

Lineage for d1w4zb1 (1w4z B:1-261)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
   has additional subdomain(s) that are not in the common domain
   

6. Protein beta-keto acyl carrier protein reductase [51788] (8 species)

7. Species Streptomyces coelicolor [TaxId:1902] [117408] (8 PDB entries)
   Uniprot P16544 #SP

8. Domain d1w4zb1: 1w4z B:1-261 [114196]
   Other proteins in same PDB: d1w4zb2
   complexed with fmt, nap

Details for d1w4zb1

PDB Entry: 1w4z, 2.5 Å

PDB Description: structure of actinorhodin polyketide (actiii) reductase

PDB Compounds: (B:) ketoacyl reductase

SCOPe Domain Sequences for d1w4zb1:

Sequence, based on SEQRES records:

>d1w4zb1 c.2.1.2 (B:1-261) beta-keto acyl carrier protein reductase {Streptomyces coelicolor [TaxId: 1902]}
matqdsevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelreagveadgr
tcdvrsvpeiealvaavverygpvdvlvnnagrpgggataeladelwldvvetnltgvfr
vtkqvlkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalglelartgi
tvnavcpgfvetpmaasvrehysdiwevsteeafdritarvpigryvqpsevaemvayli
gpgaaavtaqalnvcgglgny

Sequence, based on observed residues (ATOM records):

>d1w4zb1 c.2.1.2 (B:1-261) beta-keto acyl carrier protein reductase {Streptomyces coelicolor [TaxId: 1902]}
matqdsevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelreagveadgr
tcdvrsvpeiealvaavverygpvdvlvnnagrpgggataeladelwldvvetnltgvfr
vtkqvlkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalglelartgi
tvnavcpgfvetpmaasvrehyteeafdritarvpigryvqpsevaemvayligpgaaav
taqalnvcgglgny

Timeline for d1w4zb1:

• d1w4zb1 first appeared in SCOP 1.71, called d1w4zb_
  
• d1w4zb1 appears in SCOPe 2.07