Lineage for d1w3c.2 (1w3c B:,D:)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2055629Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 2055630Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) (S)
  5. 2057706Family b.47.1.3: Viral proteases [50596] (5 protein domains)
    beta sheet in the first domain is opened rather than forms a barrel
  6. 2057707Protein NS3 protease [50600] (5 species)
  7. 2057717Species Human hepatitis C virus (HCV), different isolates [TaxId:11103] [50601] (14 PDB entries)
    Uniprot P27958 1027-1206,1678-1669
    Uniprot P26662 1029-1202,1677-1689
    Uniprot O36579 1054-1207
  8. 2057740Domain d1w3c.2: 1w3c B:,D: [114139]
    complexed with dn1, dn2

Details for d1w3c.2

PDB Entry: 1w3c (more details), 2.3 Å

PDB Description: crystal structure of the hepatitis c virus ns3 protease in complex with a peptidomimetic inhibitor
PDB Compounds: (B:) protease/helicase ns3 (p70), (D:) nonstructural protein ns4a (p4)

SCOPe Domain Sequences for d1w3c.2:

Sequence; same for both SEQRES and ATOM records: (download)

>g1w3c.2 b.47.1.3 (B:,D:) NS3 protease {Human hepatitis C virus (HCV), different isolates [TaxId: 11103]}

SCOPe Domain Coordinates for d1w3c.2:

Click to download the PDB-style file with coordinates for d1w3c.2.
(The format of our PDB-style files is described here.)

Timeline for d1w3c.2: