SCOPe 2.05: Domain d1v8bd1: 1v8b D:235-397

Lineage for d1v8bd1 (1v8b D:235-397)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.4: Formate/glycerate dehydrogenases, NAD-domain [51830] (10 proteins)
   this domain interrupts the other domain which defines family

6. Protein S-adenosylhomocystein hydrolase [51845] (3 species)

7. Species Plasmodium falciparum, isolate 3D7 [TaxId:5833] [117431] (1 PDB entry)
   Uniprot P50250

8. Domain d1v8bd1: 1v8b D:235-397 [113570]
   Other proteins in same PDB: d1v8ba2, d1v8bb2, d1v8bc2, d1v8bd2
   complexed with adn, nad

Details for d1v8bd1

PDB Entry: 1v8b, 2.4 Å

PDB Description: Crystal structure of a hydrolase

PDB Compounds: (D:) Adenosylhomocysteinase

SCOPe Domain Sequences for d1v8bd1:

Sequence; same for both SEQRES and ATOM records:

>d1v8bd1 c.2.1.4 (D:235-397) S-adenosylhomocystein hydrolase {Plasmodium falciparum, isolate 3D7 [TaxId: 5833]}
nvygcrhslpdglmratdflisgkivvicgygdvgkgcassmkglgarvyiteidpicai
qavmegfnvvtldeivdkgdffitctgnvdviklehllkmknnavvgnighfddeiqvne
lfnykgihienvkpqvdritlpngnkiivlargrllnlgcatg

Timeline for d1v8bd1:

• d1v8bd1 first appeared in SCOP 1.71
  
• d1v8bd1 appears in SCOPe 2.04
  
• d1v8bd1 appears in SCOPe 2.06
  
• d1v8bd1 appears in the current release, SCOPe 2.08