SCOPe 2.08: Domain d1u8vc2: 1u8v C:1-275

Lineage for d1u8vc2 (1u8v C:1-275)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.6: Acyl-CoA dehydrogenase NM domain-like [56644] (1 superfamily)
   2 domains: (1) all-alpha: 5 helices; (2) contains an open beta-sheet barrel: n*=5, S*=8; complex topology

4. Superfamily e.6.1: Acyl-CoA dehydrogenase NM domain-like [56645] (3 families)
   flavoprotein: binds FAD; constituent families differ in the numbers of C-terminal domains (four-helical bundles)

5. Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains [56646] (10 proteins)

6. Protein 4-hydroxybutyryl-CoA dehydratase AbfD, NM domains [118187] (1 species)

7. Species Clostridium aminobutyricum [TaxId:33953] [118188] (1 PDB entry)
   Uniprot P55792

8. Domain d1u8vc2: 1u8v C:1-275 [113201]
   Other proteins in same PDB: d1u8va1, d1u8vb1, d1u8vc1, d1u8vd1
   complexed with fad, sf4

Details for d1u8vc2

PDB Entry: 1u8v, 1.6 Å

PDB Description: crystal structure of 4-hydroxybutyryl-coa dehydratase from clostridium aminobutyricum: radical catalysis involving a [4fe-4s] cluster and flavin

PDB Compounds: (C:) Gamma-aminobutyrate metabolism dehydratase/isomerase

SCOPe Domain Sequences for d1u8vc2:

Sequence; same for both SEQRES and ATOM records:

>d1u8vc2 e.6.1.1 (C:1-275) 4-hydroxybutyryl-CoA dehydratase AbfD, NM domains {Clostridium aminobutyricum [TaxId: 33953]}
mlmtaeqyieslrklntrvymfgekienwvdhpmirpsincvrmtyelaqdpqyadlmtt
ksnligktinrfanlhqstddlrkkvkmqrllgqktascfqrcvgmdafnavfsttyeid
qkygtnyhknfteylkyiqendlivdgamtdpkgdrglapsaqkdpdlflrivekredgi
vvrgakahqtgsinshehiimptiamteadkdyavsfacpsdadglfmiygrqscdtrkm
eegadidlgnkqfggqealvvfdnvfipndriflc

Timeline for d1u8vc2:

• d1u8vc2 first appeared in SCOP 1.71
  
• d1u8vc2 appears in SCOPe 2.07