SCOP 1.71: Domain d1u7td_: 1u7t D:

Lineage for d1u7td_ (1u7t D:)

1. Root: SCOP 1.71

2. Class c: Alpha and beta proteins (a/b) [51349] (134 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (53 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Type II 3-hydroxyacyl-CoA dehydrogenase [63933] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [102152] (2 PDB entries)

8. Domain d1u7td_: 1u7t D: [113102]
   complexed with nad, tdt; mutant

Details for d1u7td_

PDB Entry: 1u7t, 2 Å

PDB Description: crystal structure of abad/hsd10 with a bound inhibitor

SCOP Domain Sequences for d1u7td_:

Sequence; same for both SEQRES and ATOM records:

>d1u7td_ c.2.1.2 (D:) Type II 3-hydroxyacyl-CoA dehydrogenase {Human (Homo sapiens)}
svkglvavitggasglglataerlvgqgasavlldlpnsggeaqakklgnncvfapadvt
sekdvqtalalakgkfgrvdvavncagiavasktynlkkgqthtledfqrvldvnlmgtf
nvirlvagemgqnepdqggqrgviintasvaafegqvgqaaysaskggivgmtlpiardl
apigirvmtiapglfgtplltslpekvrnflasqvpfpsrlgdpaeyahlvqaiienpfl
ngevirldgairmqp

Timeline for d1u7td_:

• d1u7td_ is new in SCOP 1.71
  
• d1u7td_ appears in SCOP 1.73
  
• d1u7td_ appears in the current release, SCOPe 2.08