SCOPe 2.08: Domain d1s9ib_: 1s9i B:

Lineage for d1s9ib_ (1s9i B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Dual specificity mitogen-activated protein kinase kinase 2, Mek2 [118135] (1 species)
   OPK group (?); MAPKK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118136] (1 PDB entry)
   Uniprot P36507 60-393

8. Domain d1s9ib_: 1s9i B: [112048]
   complexed with 5ea, atp, mg

Details for d1s9ib_

PDB Entry: 1s9i, 3.2 Å

PDB Description: X-ray structure of the human mitogen-activated protein kinase kinase 2 (MEK2)in a complex with ligand and MgATP

PDB Compounds: (B:) Dual specificity mitogen-activated protein kinase kinase 2

SCOPe Domain Sequences for d1s9ib_:

Sequence, based on SEQRES records:

>d1s9ib_ d.144.1.7 (B:) Dual specificity mitogen-activated protein kinase kinase 2, Mek2 {Human (Homo sapiens) [TaxId: 9606]}
tqkakvgelkdddferiselgagnggvvtkvqhrpsglimarklihleikpairnqiire
lqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkeakripeeilgkvsiavl
rglaylrekhqimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmansfvgtrsymaper
lqgthysvqsdiwsmglslvelavgrypipppdakeleaifgrpvvdgeegephsisprp
rppgrpvsghgmdsrpamaifelldyivnepppklpngvftpdfqefvnkcliknpaera
dlkmltnhtfikrseveevdfagwlcktlrl

Sequence, based on observed residues (ATOM records):

>d1s9ib_ d.144.1.7 (B:) Dual specificity mitogen-activated protein kinase kinase 2, Mek2 {Human (Homo sapiens) [TaxId: 9606]}
tqkakvgelkdddferiselgagnggvvtkvqhrpsglimarklihleikpairnqiire
lqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkeakripeeilgkvsiavl
rglaylrekhqimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmtrsymaperlqgthy
svqsdiwsmglslvelavgrypipppdakeleaifgrmaifelldyivnepppklpngvf
tpdfqefvnkcliknpaeradlkmltnhtfikrseveevdfagwlcktlrl

Timeline for d1s9ib_:

• d1s9ib_ first appeared in SCOP 1.71
  
• d1s9ib_ appears in SCOPe 2.07