Class d: Alpha and beta proteins (a+b) [53931] (388 folds) |
Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily) consists of two alpha+beta domains, C-terminal domain is mostly alpha helical |
Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) shares functional and structural similarities with the ATP-grasp fold and PIPK |
Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins) members organized in the groups and subfamiles specified by the comments |
Protein Dual specificity mitogen-activated protein kinase kinase 2, Mek2 [118135] (1 species) OPK group (?); MAPKK subfamily; serine/threonine kinase |
Species Human (Homo sapiens) [TaxId:9606] [118136] (1 PDB entry) Uniprot P36507 60-393 |
Domain d1s9ia_: 1s9i A: [112047] complexed with 5ea, atp, mg |
PDB Entry: 1s9i (more details), 3.2 Å
SCOPe Domain Sequences for d1s9ia_:
Sequence, based on SEQRES records: (download)
>d1s9ia_ d.144.1.7 (A:) Dual specificity mitogen-activated protein kinase kinase 2, Mek2 {Human (Homo sapiens) [TaxId: 9606]} qkakvgelkdddferiselgagnggvvtkvqhrpsglimarklihleikpairnqiirel qvlhecnspyivgfygafysdgeisicmehmdggsldqvlkeakripeeilgkvsiavlr glaylrekhqimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmansfvgtrsymaperl qgthysvqsdiwsmglslvelavgrypipppdakeleaifgrpvvdgeegephsisprpr ppgrpvsghgmdsrpamaifelldyivnepppklpngvftpdfqefvnkcliknpaerad lkmltnhtfikrseveevdfagwlcktlrlnqpg
>d1s9ia_ d.144.1.7 (A:) Dual specificity mitogen-activated protein kinase kinase 2, Mek2 {Human (Homo sapiens) [TaxId: 9606]} qkakvgelkdddferiselgagnggvvtkvqhrpsglimarklihleikpairnqiirel qvlhecnspyivgfygafysdgeisicmehmdggsldqvlkeakripeeilgkvsiavlr glaylrekhqimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmvgtrsymaperlqgth ysvqsdiwsmglslvelavgrypipppdakeleaifgrpvvdrpamaifelldyivnepp pklpngvftpdfqefvnkcliknpaeradlkmltnhtfikrseveevdfagwlcktlrln qpg
Timeline for d1s9ia_: