SCOPe 2.05: Domain d1s9ia_: 1s9i A:

Lineage for d1s9ia_ (1s9i A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Dual specificity mitogen-activated protein kinase kinase 2, Mek2 [118135] (1 species)
   OPK group (?); MAPKK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118136] (1 PDB entry)
   Uniprot P36507 60-393

8. Domain d1s9ia_: 1s9i A: [112047]
   complexed with 5ea, atp, mg

Details for d1s9ia_

PDB Entry: 1s9i, 3.2 Å

PDB Description: X-ray structure of the human mitogen-activated protein kinase kinase 2 (MEK2)in a complex with ligand and MgATP

PDB Compounds: (A:) Dual specificity mitogen-activated protein kinase kinase 2

SCOPe Domain Sequences for d1s9ia_:

Sequence, based on SEQRES records:

>d1s9ia_ d.144.1.7 (A:) Dual specificity mitogen-activated protein kinase kinase 2, Mek2 {Human (Homo sapiens) [TaxId: 9606]}
qkakvgelkdddferiselgagnggvvtkvqhrpsglimarklihleikpairnqiirel
qvlhecnspyivgfygafysdgeisicmehmdggsldqvlkeakripeeilgkvsiavlr
glaylrekhqimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmansfvgtrsymaperl
qgthysvqsdiwsmglslvelavgrypipppdakeleaifgrpvvdgeegephsisprpr
ppgrpvsghgmdsrpamaifelldyivnepppklpngvftpdfqefvnkcliknpaerad
lkmltnhtfikrseveevdfagwlcktlrlnqpg

Sequence, based on observed residues (ATOM records):

>d1s9ia_ d.144.1.7 (A:) Dual specificity mitogen-activated protein kinase kinase 2, Mek2 {Human (Homo sapiens) [TaxId: 9606]}
qkakvgelkdddferiselgagnggvvtkvqhrpsglimarklihleikpairnqiirel
qvlhecnspyivgfygafysdgeisicmehmdggsldqvlkeakripeeilgkvsiavlr
glaylrekhqimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmvgtrsymaperlqgth
ysvqsdiwsmglslvelavgrypipppdakeleaifgrpvvdrpamaifelldyivnepp
pklpngvftpdfqefvnkcliknpaeradlkmltnhtfikrseveevdfagwlcktlrln
qpg

Timeline for d1s9ia_:

• d1s9ia_ first appeared in SCOP 1.71
  
• d1s9ia_ appears in SCOPe 2.04
  
• d1s9ia_ appears in SCOPe 2.06
  
• d1s9ia_ appears in the current release, SCOPe 2.08