SCOPe 2.05: Domain d1rww.1: 1rww A:,B:

Lineage for d1rww.1 (1rww A:,B:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.17: Caspase-like [52128] (1 superfamily)
   3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest

4. Superfamily c.17.1: Caspase-like [52129] (3 families)
   mature protein may be composed of two chains folded in a single domain

5. Family c.17.1.1: Caspase catalytic domain [52130] (8 proteins)

6. Protein Interleukin-1beta converting enzyme (a cysteine protease) [52133] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [52134] (14 PDB entries)
   Uniprot P29466 125-297,317-404

8. Domain d1rww.1: 1rww A:,B: [111957]
   complexed with oqb

Details for d1rww.1

PDB Entry: 1rww, 2.8 Å

PDB Description: Crystal structure of human caspase-1 in complex with 4-oxo-3-[(6-{[4-(quinoxalin-2-ylamino)-benzoylamino]-methyl}-pyridine-3-carbonyl)-amino]-butyric acid

PDB Compounds: (A:) Interleukin-1 beta convertase, (B:) Interleukin-1 beta convertase

SCOPe Domain Sequences for d1rww.1:

Sequence; same for both SEQRES and ATOM records:

>g1rww.1 c.17.1.1 (A:,B:) Interleukin-1beta converting enzyme (a cysteine protease) {Human (Homo sapiens) [TaxId: 9606]}
mptssgsegnvklcsleeaqriwkqksaeiypimdkssrtrlaliicneefdsiprrtga
evditgmtmllqnlgysvdvkknltasdmtteleafahrpehktsdstflvfmshgireg
icgkkhseqvpdilqlnaifnmlntkncpslkdkpkviiiqacrgdspgvvwfkdXaikk
ahiekdfiafcsstpdnvswrhptmgsvfigrliehmqeyacscdveeifrkvrfsfeqp
dgraqmpttervtltrcfylfpgh

Timeline for d1rww.1:

• d1rww.1 first appeared in SCOP 1.71
  
• d1rww.1 appears in SCOPe 2.04
  
• d1rww.1 appears in SCOPe 2.06
  
• d1rww.1 appears in the current release, SCOPe 2.08