SCOPe 2.05: Domain d1rwk.1: 1rwk A:,B:

Lineage for d1rwk.1 (1rwk A:,B:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.17: Caspase-like [52128] (1 superfamily)
   3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest

4. Superfamily c.17.1: Caspase-like [52129] (3 families)
   mature protein may be composed of two chains folded in a single domain

5. Family c.17.1.1: Caspase catalytic domain [52130] (8 proteins)

6. Protein Interleukin-1beta converting enzyme (a cysteine protease) [52133] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [52134] (14 PDB entries)
   Uniprot P29466 125-297,317-404

8. Domain d1rwk.1: 1rwk A:,B: [111946]
   complexed with 158

Details for d1rwk.1

PDB Entry: 1rwk, 2.3 Å

PDB Description: Crystal structure of human caspase-1 in complex with 3-(2-mercapto-acetylamino)-4-oxo-pentanoic acid

PDB Compounds: (A:) Interleukin-1 beta convertase, (B:) Interleukin-1 beta convertase

SCOPe Domain Sequences for d1rwk.1:

Sequence; same for both SEQRES and ATOM records:

>g1rwk.1 c.17.1.1 (A:,B:) Interleukin-1beta converting enzyme (a cysteine protease) {Human (Homo sapiens) [TaxId: 9606]}
tssgsegnvklcsleeaqriwkqksaeiypimdkssrtrlaliicneefdsiprrtgaev
ditgmtmllqnlgysvdvkknltasdmtteleafahrpehktsdstflvfmshgiregic
gkkhseqvpdilqlnaifnmlntkncpslkdkpkviiiqacrgdspgvvwfkdXaikkah
iekdfiafcsstpdnvswrhptmgsvfigrliehmqeyacscdveeifrkvrfsfeqpdg
raqmpttervtltrcfylfpgh

Timeline for d1rwk.1:

• d1rwk.1 first appeared in SCOP 1.71
  
• d1rwk.1 appears in SCOPe 2.04
  
• d1rwk.1 appears in SCOPe 2.06
  
• d1rwk.1 appears in the current release, SCOPe 2.08