SCOPe 2.07: Domain d1rdtd1: 1rdt D:207-477

Lineage for d1rdtd1 (1rdt D:207-477)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Peroxisome proliferator activated receptor gamma, PPAR-gamma [48524] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48525] (167 PDB entries)
   Uniprot P37231 232-505

8. Domain d1rdtd1: 1rdt D:207-477 [111788]
   Other proteins in same PDB: d1rdta_, d1rdtd2
   complexed with co-activator peptide
   complexed with 570, l79

Details for d1rdtd1

PDB Entry: 1rdt, 2.4 Å

PDB Description: Crystal Structure of a new rexinoid bound to the RXRalpha ligand binding doamin in the RXRalpha/PPARgamma heterodimer

PDB Compounds: (D:) Peroxisome proliferator activated receptor gamma

SCOPe Domain Sequences for d1rdtd1:

Sequence, based on SEQRES records:

>d1rdtd1 a.123.1.1 (D:207-477) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens) [TaxId: 9606]}
esadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkikfkh
itplqeqskevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheii
ytmlaslmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlai
fiaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqiv
tehvqllqvikktetdmslhpllqeiykdly

Sequence, based on observed residues (ATOM records):

>d1rdtd1 a.123.1.1 (D:207-477) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens) [TaxId: 9606]}
esadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmevairifqgc
qfrsveavqeiteyaksipgfvnldlndqvtllkygvheiiytmlaslmnkdgvlisegq
gfmtreflkslrkpfgdfmepkfefavkfnalelddsdlaifiaviilsgdrpgllnvkp
iediqdnllqalelqlklnhpessqlfakllqkmtdlrqivtehvqllqvikktetdmsl
hpllqeiykdly

Timeline for d1rdtd1:

• d1rdtd1 first appeared in SCOP 1.71, called d1rdtd_
  
• d1rdtd1 appears in SCOPe 2.06
  
• d1rdtd1 appears in the current release, SCOPe 2.08