SCOPe 2.08: Domain d1rdta_: 1rdt A:

Lineage for d1rdta_ (1rdt A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Retinoid-X receptor alpha (RXR-alpha) [48510] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48511] (38 PDB entries)
   Uniprot P19793 227-458

8. Domain d1rdta_: 1rdt A: [111787]
   Other proteins in same PDB: d1rdtd1, d1rdtd2
   complexed with co-activator peptide
   complexed with 570, l79

Details for d1rdta_

PDB Entry: 1rdt, 2.4 Å

PDB Description: Crystal Structure of a new rexinoid bound to the RXRalpha ligand binding doamin in the RXRalpha/PPARgamma heterodimer

PDB Compounds: (A:) Retinoic acid receptor RXR-alpha

SCOPe Domain Sequences for d1rdta_:

Sequence, based on SEQRES records:

>d1rdta_ a.123.1.1 (A:) Retinoid-X receptor alpha (RXR-alpha) {Human (Homo sapiens) [TaxId: 9606]}
edmpverileaelavepktetyveanmglnpsspndpvtnicqaadkqlftlvewakrip
hfselplddqvillragwnelliasfshrsiavkdgillatglhvhrnsahsagvgaifd
rvltelvskmrdmqmdktelgclraivlfnpdskglsnpaevealrekvyasleayckhk
ypeqpgrfaklllrlpalrsiglkclehlfffkligdtpidtflmemle

Sequence, based on observed residues (ATOM records):

>d1rdta_ a.123.1.1 (A:) Retinoid-X receptor alpha (RXR-alpha) {Human (Homo sapiens) [TaxId: 9606]}
edmpverileaelavepdpvtnicqaadkqlftlvewakriphfselplddqvillragw
nelliasfshrsiavkdgillatglhvhrnsahsagvgaifdrvltelvskmrdmqmdkt
elgclraivlfnpdskglsnpaevealrekvyasleayckhkypeqpgrfaklllrlpal
rsiglkclehlfffkligdtpidtflmemle

Timeline for d1rdta_:

• d1rdta_ first appeared in SCOP 1.71
  
• d1rdta_ appears in SCOPe 2.07