SCOPe 2.07: Family g.37.1.4: HkH motif-containing C2H2 finger

Lineage for Family g.37.1.4: HkH motif-containing C2H2 finger

1. Root: SCOPe 2.07

2. Class g: Small proteins [56992] (98 folds)

3. Fold g.37: beta-beta-alpha zinc fingers [57666] (1 superfamily)
   simple fold, consisting of the N-terminal beta-hairpin and C-terminal alpha-helical region; each part provides two zinc-coordinating residues with the observed sequences including C2H2, C2HC and CHHC

4. Superfamily g.37.1: beta-beta-alpha zinc fingers [57667] (8 families)

5. Family g.37.1.4: HkH motif-containing C2H2 finger [111436] (4 proteins)
   putative dsRNA-specific zinc finger with a helix-kink-helix (HkH) motif; the kink results from the incompatibility of the cation-coordinating H-x5-H motif with a regular alpha-helix and contributes to RNA recognition

Proteins:

1. dsRNA-binding protein ZFa (ZNF346, JAZ) [161154] (1 species)

   • Species African clawed frog (Xenopus laevis) [TaxId:8355] [161155] (1 PDB entry)
     Uniprot Q8AVN9 2-73!Uniprot Q8AVN9 74-128

2. Spliceosomal protein U1C [111437] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [111438] (1 PDB entry)
     Uniprot P09234 1-61

3. Zinc finger homeobox protein 4, ZFHX4 [161156] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [161157] (1 PDB entry)
     Uniprot Q9JJN9 2937-2984

4. Zinc finger protein 593, ZNF593 [144151] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [144152] (1 PDB entry)
     Uniprot O00488 28-94

More info for Family g.37.1.4: HkH motif-containing C2H2 finger

Timeline for Family g.37.1.4: HkH motif-containing C2H2 finger:

• Family g.37.1.4: HkH motif-containing C2H2 finger first appeared in SCOP 1.69, called Family g.37.1.4: Spliceosomal protein U1C
  
• Family g.37.1.4: HkH motif-containing C2H2 finger appears in SCOPe 2.06
  
• Family g.37.1.4: HkH motif-containing C2H2 finger appears in the current release, SCOPe 2.08