Class c: Alpha and beta proteins (a/b) [51349] (134 folds) |
Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily) consists of two intertwined (sub)domains related by pseudo dyad; duplication 3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest |
Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (5 families) the constituent families form similar dimers |
Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (3 proteins) the active site is between the two identical subunits |
Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species) |
Species Human (Homo sapiens) [TaxId:9606] [110715] (2 PDB entries) |
Domain d1t09a_: 1t09 A: [106197] |
Domain d1t09b_: 1t09 B: [106198] complexed with nap |
Domain d1t0la_: 1t0l A: [106216] |
Domain d1t0lb_: 1t0l B: [106217] |
Domain d1t0lc_: 1t0l C: [106218] |
Domain d1t0ld_: 1t0l D: [106219] complexed with ca, ict, nap |
Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.77.1.1 NADP-dependent isocitrate dehydrogenase: