SCOPe 2.08: Domain d1w2cb_: 1w2c B:

Lineage for d1w2cb_ (1w2c B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.143: SAICAR synthase-like [56103] (1 superfamily)
   consists of two alpha+beta subdomains

4. Superfamily d.143.1: SAICAR synthase-like [56104] (4 families)
   shares functional and structural similarities with the ATP-grasp fold and protein kinase superfamilies

5. Family d.143.1.3: Inositol polyphosphate kinase (IPK) [111188] (2 proteins)
   Pfam PF03770

6. Protein Inositol 1,4,5-trisphosphate 3-kinase A, IP3K A [111189] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [111190] (3 PDB entries)
   Uniprot P23677 187-461

8. Domain d1w2cb_: 1w2c B: [109120]
   complexed with anp, i3p, mn, so4

Details for d1w2cb_

PDB Entry: 1w2c, 1.95 Å

PDB Description: human inositol (1,4,5) trisphosphate 3-kinase complexed with mn2+/amppnp/ins(1,4,5)p3

PDB Compounds: (B:) inositol-trisphosphate 3-kinase a

SCOPe Domain Sequences for d1w2cb_:

Sequence, based on SEQRES records:

>d1w2cb_ d.143.1.3 (B:) Inositol 1,4,5-trisphosphate 3-kinase A, IP3K A {Human (Homo sapiens) [TaxId: 9606]}
sfkaagtsglilkrcseperyclarlmadalrgcvpafhgvverdgesylqlqdlldgfd
gpcvldckmgvrtyleeeltkarerpklrkdmykkmlavdpeapteeehaqravtkprym
qwregisssttlgfriegikkadgscstdfkttrsreqvlrvfeefvqgdeevlrrylnr
lqqirdtlevseffrrhevigssllfvhdhchragvwlidfgkttplpdgqildhrrpwe
egnredgyllgldnligilaslaer

Sequence, based on observed residues (ATOM records):

>d1w2cb_ d.143.1.3 (B:) Inositol 1,4,5-trisphosphate 3-kinase A, IP3K A {Human (Homo sapiens) [TaxId: 9606]}
sfkaagtsglilkrcseperyclarlmadalrgcvpafhgvverdgesylqlqdlldgfd
gpcvldckmgvrtyleeeltkklrkdmykkmlavdpavtkprymqwregisssttlgfri
egikkadgscstdfkttrsreqvlrvfeefvqgdeevlrrylnrlqqirdtlevseffrr
hevigssllfvhdhchragvwlidfgkttplpdgqildhrrpweegnredgyllgldnli
gilaslaer

Timeline for d1w2cb_:

• d1w2cb_ first appeared in SCOP 1.69
  
• d1w2cb_ appears in SCOPe 2.07