SCOPe 2.08: Domain d1w22a_: 1w22 A:

Lineage for d1w22a_ (1w22 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.42: Arginase/deacetylase [52767] (1 superfamily)
   3 layers: a/b/a, parallel beta-sheet of 8 strands, order 21387456

4. Superfamily c.42.1: Arginase/deacetylase [52768] (3 families)

5. Family c.42.1.2: Histone deacetylase, HDAC [52773] (4 proteins)
   automatically mapped to Pfam PF00850

6. Protein Histone deacetylase 8, HDAC8 [110587] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [110588] (5 PDB entries)
   Uniprot Q9BY41 13-375 ! Uniprot Q9BY41

8. Domain d1w22a_: 1w22 A: [109083]
   complexed with k, nhb, zn

Details for d1w22a_

PDB Entry: 1w22, 2.5 Å

PDB Description: Crystal structure of inhibited human HDAC8

PDB Compounds: (A:) Histone deacetylase 8

SCOPe Domain Sequences for d1w22a_:

Sequence, based on SEQRES records:

>d1w22a_ c.42.1.2 (A:) Histone deacetylase 8, HDAC8 {Human (Homo sapiens) [TaxId: 9606]}
slvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpkvasmeematfht
daylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggatitaaqclidgmck
vainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsft
skvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevy
qafnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggynlanta
rcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgn
lkh

Sequence, based on observed residues (ATOM records):

>d1w22a_ c.42.1.2 (A:) Histone deacetylase 8, HDAC8 {Human (Homo sapiens) [TaxId: 9606]}
slvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpkvasmeematfht
daylqhlqkvsqeyglgydcpategifdyaaaiggatitaaqclidgmckvainwsggwh
hakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsftskvmtvslhk
fspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyqafnpkavvl
qlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggynlantarcwtyltgvi
lgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnlkh

Timeline for d1w22a_:

• d1w22a_ first appeared in SCOP 1.69
  
• d1w22a_ appears in SCOPe 2.07