SCOPe 2.08: Domain d1vzoa_: 1vzo A:

Lineage for d1vzoa_ (1vzo A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Ribosomal protein S6 kinase alpha 5, Msk1 [111192] (1 species)
   AGC group (?); S6 kinase subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [111193] (1 PDB entry)
   Uniprot O75582 24-345

8. Domain d1vzoa_: 1vzo A: [108971]
   complexed with bme, so4

Details for d1vzoa_

PDB Entry: 1vzo, 1.8 Å

PDB Description: the structure of the n-terminal kinase domain of msk1 reveals a novel autoinhibitory conformation for a dual kinase protein

PDB Compounds: (A:) ribosomal protein s6 kinase alpha 5

SCOPe Domain Sequences for d1vzoa_:

Sequence, based on SEQRES records:

>d1vzoa_ d.144.1.7 (A:) Ribosomal protein S6 kinase alpha 5, Msk1 {Human (Homo sapiens) [TaxId: 9606]}
qlltvkhelrtanltghaekvgienfellkvlgtgaygkvflvrkisghdtgklyamkvl
kkativqkakttehtrterqvlehirqspflvtlhyafqtetklhlildyinggelfthl
sqrerftehevqiyvgeivlalehlhklgiiyrdiklenilldsnghvvltdfglskefv
adeteraydfcgtieymapdivrggdsghdkavdwwslgvlmyelltgaspftvdgekns
qaeisrrilkseppypqemsalakdliqrllmkdpkkrlgcgprdadeikehlffqkinw
ddlaakkvpapfkpvirdeldv

Sequence, based on observed residues (ATOM records):

>d1vzoa_ d.144.1.7 (A:) Ribosomal protein S6 kinase alpha 5, Msk1 {Human (Homo sapiens) [TaxId: 9606]}
qlltvkhelrtanltghaekvgienfellkvlgtgaygkvflvrkisghdtgklyamkvl
kkativqkakttehtrterqvlehirqspflvtlhyafqtetklhlildyinggelfthl
sqrerftehevqiyvgeivlalehlhklgiiyrdiklenilldsnghvvltdfglskefv
adeteraydfcgtieymapdivrggddkavdwwslgvlmyelltgaspftvdgeknsqae
isrrilkseppypqemsalakdliqrllmkdpkkrlgcgprdadeikehlffqkinwddl
aakkvpapfkpvirdeldv

Timeline for d1vzoa_:

• d1vzoa_ first appeared in SCOP 1.69
  
• d1vzoa_ appears in SCOPe 2.07