SCOP 1.69: Domain d1uxka1: 1uxk A:2-143

Lineage for d1uxka1 (1uxk A:2-143)

1. Root: SCOP 1.69

2. Class c: Alpha and beta proteins (a/b) [51349] (136 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.5: LDH N-terminal domain-like [51848] (8 proteins)

6. Protein Malate dehydrogenase [51849] (12 species)

7. Species Chloroflexus aurantiacus [69415] (7 PDB entries)

8. Domain d1uxka1: 1uxk A:2-143 [108116]
   Other proteins in same PDB: d1uxka2, d1uxkc2

Details for d1uxka1

PDB Entry: 1uxk, 1.8 Å

PDB Description: large improvement in the thermal stability of a tetrameric malate dehydrogenase by single point mutations at the dimer-dimer interface

SCOP Domain Sequences for d1uxka1:

Sequence, based on SEQRES records:

>d1uxka1 c.2.1.5 (A:2-143) Malate dehydrogenase {Chloroflexus aurantiacus}
rkkisiigagfvgsttahwlaakelgdivlldivegvpqgkaldlyeaspiegfdvrvtg
tnnyadtansdvivvtsgaprkpgmsredlikvnaditracisqaaplspnaviimvnnp
ldamtylaaevsgfpkervigq

Sequence, based on observed residues (ATOM records):

>d1uxka1 c.2.1.5 (A:2-143) Malate dehydrogenase {Chloroflexus aurantiacus}
rkkisiigagfvgsttahwlaakelgdivlldivegvpqgkaldlyeaspiegfdvrvtg
tnnyadtansdvivvtsgaikvnaditracisqaaplspnaviimvnnpldamtylaaev
sgfpkervigq

Timeline for d1uxka1:

• d1uxka1 is new in SCOP 1.69
  
• d1uxka1 appears in SCOP 1.71
  
• d1uxka1 appears in the current release, SCOPe 2.08