SCOPe 2.08: Domain d1uxia2: 1uxi A:144-307

Lineage for d1uxia2 (1uxi A:144-307)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.162: LDH C-terminal domain-like [56326] (1 superfamily)
   unusual fold, defines family

4. Superfamily d.162.1: LDH C-terminal domain-like [56327] (3 families)

5. Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain [56328] (5 proteins)
   N-terminal domain is NAD-binding module (alpha/beta Rossmann-fold domain)
   automatically mapped to Pfam PF02866

6. Protein Malate dehydrogenase [56329] (12 species)

7. Species Chloroflexus aurantiacus [TaxId:1108] [69840] (7 PDB entries)
   Uniprot P80040

8. Domain d1uxia2: 1uxi A:144-307 [108109]
   Other proteins in same PDB: d1uxia1, d1uxib1
   complexed with fum, na, nad; mutant

Details for d1uxia2

PDB Entry: 1uxi, 2.1 Å

PDB Description: large improvement in the thermal stability of a tetrameric malate dehydrogenase by single point mutations at the dimer-dimer interface

PDB Compounds: (A:) malate dehydrogenase

SCOPe Domain Sequences for d1uxia2:

Sequence; same for both SEQRES and ATOM records:

>d1uxia2 d.162.1.1 (A:144-307) Malate dehydrogenase {Chloroflexus aurantiacus [TaxId: 1108]}
agvldaaryrtfiameagvsvkdvqamlmgghgdemvplprfstisgipvsefiapdrla
qivertrkgggeivnllktgsayyapaaataqmveavlkdkkrvmpvaayltgqyglndi
yfgvpvilgaggvekilelplneeemallnasakavratldtlk

Timeline for d1uxia2:

• d1uxia2 first appeared in SCOP 1.69
  
• d1uxia2 appears in SCOPe 2.07