SCOPe 2.05: Domain d1ukia_: 1uki A:

Lineage for d1ukia_ (1uki A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Mitogen-activated protein kinase 8 (jnk1) [111202] (1 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [111203] (2 PDB entries)
   Uniprot P45983 9-363

8. Domain d1ukia_: 1uki A: [107914]
   complexed with 537

Details for d1ukia_

PDB Entry: 1uki, 2.7 Å

PDB Description: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125

PDB Compounds: (A:) mitogen-activated protein kinase 8 isoform 4

SCOPe Domain Sequences for d1ukia_:

Sequence, based on SEQRES records:

>d1ukia_ d.144.1.7 (A:) Mitogen-activated protein kinase 8 (jnk1) {Human (Homo sapiens) [TaxId: 9606]}
nfysveigdstftvlkryqnlkpigsgaqgivcaaydailernvaikklsrpfqnqthak
rayrelvlmkcvnhkniigllnvftpqksleefqdvyivmelmdanlcqviqmeldherm
syllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartagtsfmmtpyvvt
ryyrapevilgmgykenvdiwsvgcimgemikggvlfpgtdhidqwnkvieqlgtpcpef
mkklqptvrtyvenrpkyagysfeklfpdvlfpadsehnklkasqardllskmlvidask
risvdealqhpyinvwydpseaeapppkipdkqlderehtieewkeliykevmdl

Sequence, based on observed residues (ATOM records):

>d1ukia_ d.144.1.7 (A:) Mitogen-activated protein kinase 8 (jnk1) {Human (Homo sapiens) [TaxId: 9606]}
nfysveigdstftvlkryqnlkpigsgaqgivcaaydailernvaikklsrpfqnqthak
rayrelvlmkcvnhkniigllnvftpqksleefqdvyivmelmdanlcqviqmeldherm
syllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartryyrapevilgmg
ykenvdiwsvgcimgemikggvlfpgtdhidqwnkvieqlgtpcpefmkklqptvrtyve
nrpkyagysfeklfpdvlfpnklkasqardllskmlvidaskrisvdealqhpyinvwyd
pseaeapppkihtieewkeliykevmdl

Timeline for d1ukia_:

• d1ukia_ first appeared in SCOP 1.69
  
• d1ukia_ appears in SCOPe 2.04
  
• d1ukia_ appears in SCOPe 2.06
  
• d1ukia_ appears in the current release, SCOPe 2.08