SCOPe 2.08: Domain d1ukha_: 1ukh A:

Lineage for d1ukha_ (1ukh A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Mitogen-activated protein kinase 8 (jnk1) [111202] (1 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [111203] (2 PDB entries)
   Uniprot P45983 9-363

8. Domain d1ukha_: 1ukh A: [107913]

Details for d1ukha_

PDB Entry: 1ukh, 2.35 Å

PDB Description: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125

PDB Compounds: (A:) mitogen-activated protein kinase 8 isoform 4

SCOPe Domain Sequences for d1ukha_:

Sequence, based on SEQRES records:

>d1ukha_ d.144.1.7 (A:) Mitogen-activated protein kinase 8 (jnk1) {Human (Homo sapiens) [TaxId: 9606]}
nfysveigdstftvlkryqnlkpigsgaqgivcaaydailernvaikklsrpfqnqthak
rayrelvlmkcvnhkniigllnvftpqksleefqdvyivmelmdanlcqviqmeldherm
syllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartagtsfmmtpyvvt
ryyrapevilgmgykenvdiwsvgcimgemikggvlfpgtdhidqwnkvieqlgtpcpef
mkklqptvrtyvenrpkyagysfeklfpdvlfpadsehnklkasqardllskmlvidask
risvdealqhpyinvwydpseaeapppkipdkqlderehtieewkeliykevmdl

Sequence, based on observed residues (ATOM records):

>d1ukha_ d.144.1.7 (A:) Mitogen-activated protein kinase 8 (jnk1) {Human (Homo sapiens) [TaxId: 9606]}
nfysveigdstftvlkryqnlkpigsgaqgivcaaydailernvaikklsrpfqnqthak
rayrelvlmkcvnhkniigllnvftpqksleefqdvyivmelmdanlcqviqmeldherm
syllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglyyrapevilgmgyken
vdiwsvgcimgemikggvlfpgtdhidqwnkvieqlgtpcpefmkklqptvrtyvenrpk
yagysfeklfpdvlfpnklkasqardllskmlvidaskrisvdealqhpyinvwydpsea
eapppkieewkeliykevmdl

Timeline for d1ukha_:

• d1ukha_ first appeared in SCOP 1.69
  
• d1ukha_ appears in SCOPe 2.07