SCOPe 2.04: Domain d1u59a_: 1u59 A:

Lineage for d1u59a_ (1u59 A:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Tyrosine-protein kinase ZAP-70 [111198] (1 species)
   PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [111199] (1 PDB entry)
   Uniprot P43403 328-606 # structure of the N-terminal SH2 domains (1-132;133-256) is also known: 1m61 (89997)

8. Domain d1u59a_: 1u59 A: [107681]
   complexed with stu

Details for d1u59a_

PDB Entry: 1u59, 2.3 Å

PDB Description: crystal structure of the zap-70 kinase domain in complex with staurosporine

PDB Compounds: (A:) tyrosine-protein kinase zap-70

SCOPe Domain Sequences for d1u59a_:

Sequence, based on SEQRES records:

>d1u59a_ d.144.1.7 (A:) Tyrosine-protein kinase ZAP-70 {Human (Homo sapiens) [TaxId: 9606]}
kklflkrdnlliadielgcgnfgsvrqgvyrmrkkqidvaikvlkqgtekadteemmrea
qimhqldnpyivrligvcqaealmlvmemagggplhkflvgkreeipvsnvaellhqvsm
gmkyleeknfvhrdlaarnvllvnrhyakisdfglskalgaddsyytarsagkwplkwya
pecinfrkfssrsdvwsygvtmwealsygqkpykkmkgpevmafieqgkrmecppecppe
lyalmsdcwiykwedrpdfltveqrmracyyslaskveghhhhhh

Sequence, based on observed residues (ATOM records):

>d1u59a_ d.144.1.7 (A:) Tyrosine-protein kinase ZAP-70 {Human (Homo sapiens) [TaxId: 9606]}
kklflkrdnlliadielgcgnfgsvrqgvyrkqidvaikvlkqgtekadteemmreaqim
hqldnpyivrligvcqaealmlvmemagggplhkflvgkreeipvsnvaellhqvsmgmk
yleeknfvhrdlaarnvllvnrhyakisdfglskalgaddsyytarsagkwplkwyapec
infrkfssrsdvwsygvtmwealsygqkpykkmkgpevmafieqgkrmecppecppelya
lmsdcwiykwedrpdfltveqrmracyyslaskveghhhhhh

Timeline for d1u59a_:

• d1u59a_ first appeared in SCOP 1.69
  
• d1u59a_ appears in SCOPe 2.03
  
• d1u59a_ appears in SCOPe 2.05
  
• d1u59a_ appears in the current release, SCOPe 2.08, called d1u59a1