SCOP 1.75: Domain d1u42a_: 1u42 A:

Lineage for d1u42a_ (1u42 A:)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.18: E set domains [81296] (23 families)
   "Early" Ig-like fold families possibly related to the immunoglobulin and/or fibronectin type III superfamilies

5. Family b.1.18.1: NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain [81279] (7 proteins)
   subgroup of the larger IPT/TIG domain family

6. Protein p50 subunit of NF-kappa B transcription factor [49248] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49249] (9 PDB entries)
   Uniprot P25799 245-350

8. Domain d1u42a_: 1u42 A: [107652]
   mutant

Details for d1u42a_

PDB Entry: 1u42, 2.7 Å

PDB Description: crystal structure of mlam mutant of dimerisation domain of nf-kb p50 transcription factor

PDB Compounds: (A:) Nuclear factor NF-kappa-B p105 subunit

SCOP Domain Sequences for d1u42a_:

Sequence, based on SEQRES records:

>d1u42a_ b.1.18.1 (A:) p50 subunit of NF-kappa B transcription factor {Human (Homo sapiens) [TaxId: 9606]}
snlkivrmdrtagcvtggeeimllcdkvqkddiqirfyeeeenggvwegfgdfsptdvhr
qfaimfktpkykdvnitkpasvfvqlrrksdletsepkpflyype

Sequence, based on observed residues (ATOM records):

>d1u42a_ b.1.18.1 (A:) p50 subunit of NF-kappa B transcription factor {Human (Homo sapiens) [TaxId: 9606]}
snlkivrmdrtagcvtggeeimllcdkvqkddiqirfyeegvwegfgdfsptdvhrqfai
mfktpkykdvnitkpasvfvqlrrksdletsepkpflyype

Timeline for d1u42a_:

• d1u42a_ first appeared in SCOP 1.69
  
• d1u42a_ appears in SCOP 1.73
  
• d1u42a_ appears in SCOPe 2.01
  
• d1u42a_ appears in the current release, SCOPe 2.08