SCOPe 2.08: Domain d1u2zc_: 1u2z C:

Lineage for d1u2zc_ (1u2z C:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (61 families)

5. Family c.66.1.31: Catalytic, N-terminal domain of histone methyltransferase Dot1l [89746] (2 proteins)

6. Protein Catalytic, N-terminal domain of histone methyltransferase Dot1l [89747] (2 species)
   a non-SET domain nucleosomal histone methyltransferase

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [110667] (1 PDB entry)
   Uniprot Q04089 176-581

8. Domain d1u2zc_: 1u2z C: [107628]
   complexed with sah

Details for d1u2zc_

PDB Entry: 1u2z, 2.2 Å

PDB Description: Crystal structure of histone K79 methyltransferase Dot1p from yeast

PDB Compounds: (C:) Histone-lysine N-methyltransferase, H3 lysine-79 specific

SCOPe Domain Sequences for d1u2zc_:

Sequence, based on SEQRES records:

>d1u2zc_ c.66.1.31 (C:) Catalytic, N-terminal domain of histone methyltransferase Dot1l {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
sstfvdwngpclrlqyplfdieylrsheiysgtpiqsislrtnspqptsltsdndtssvt
taklqsilfsnymeeykvdfkrstaiynpmseigklieysclvflpspyaeqlketilpd
lnasfdnsdtkgfvnainlynkmireiprqriidhletidkiprsfihdflhivytrsih
pqanklkhykafsnyvygellpnflsdvyqqcqlkkgdtfmdlgsgvgncvvqaalecgc
alsfgceimddasdltilqyeelkkrcklygmrlnnvefslkksfvdnnrvaelipqcdv
ilvnnflfdedlnkkvekilqtakvgckiislkslrsltyqinfynvenifnrlkvqryd
lkedsvswthsggeyyistvmedvdeslfspaargrrnrgtpvkytr

Sequence, based on observed residues (ATOM records):

>d1u2zc_ c.66.1.31 (C:) Catalytic, N-terminal domain of histone methyltransferase Dot1l {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
sstfvdwngpclrlqyplfdieylrsheiysgtpiqsislrtttaklqsilfsnymeeyk
vdfkrstaiynpmseigklieysclvflpspyaeqlketilpdlnasfdnsdtkgfvnai
nlynkmireiprqriidhletidkiprsfihdflhivytrsihpqanklkhykafsnyvy
gellpnflsdvyqqcqlkkgdtfmdlgsgvgncvvqaalecgcalsfgceimddasdlti
lqyeelkkrcklygmrlnnvefslkksfvdnnrvaelipqcdvilvnnflfdedlnkkve
kilqtakvgckiislkslrsltyqinfynvenifnrlkvqrydlkedsvswthsggeyyi
stvmedvdeslfspaarrtpvkytr

Timeline for d1u2zc_:

• d1u2zc_ first appeared in SCOP 1.69
  
• d1u2zc_ appears in SCOPe 2.07